Anders Skov Kristensen

2004: Ph.D. - Danish University of Pharmaceutical Sciences, Copenhagen, Denmark.
1999: M.Sc. - Aarhus University, Aarhus, Denmark.

2006-2008: Assistant professor, Dept. of Medicinal Chemistry, University of Copenhagen, Denmark.
2004-2006: Postdoctoral Fellow, Dept. of Pharmacology, Emory University School of Medicine, Emory University, Atlanta, USA.
2000-2004: Graduate student; Dept. of Pharmacology, Royal Danish School of Pharmacy and NeuroSearch A/S, Ballerup, Denmark.
1999-2000: Research assistant; Dept. of Biological Psychiatry, Aarhus Psychiatric University Hospital, Denmark.

Structure, function and regulation of neurotransmitter receptors and transporters.

Strømgaard K, Kristensen AS, (2012) A Heteromeric Snake Toxin and the Molecular Details of Pain Perception. Angewandte Chemie International, in press.

Bach A, Clausen BH, Møller M, Vestergaard B, Chi CN, Round R, Sørensen PL, Nissen KB, Kastrup JS, Gajhede M, Jemth P, Kristensen AS, Lundström P, Lambertsen KL, Strømgaard K (2012) A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. PNAS 109(9): 3317-22.

Olsen CA, Kristensen AS, Strømgaard K (2011) Small molecules from spiders as chemical probes. Angewandte Chemie International 50(48): 11296-11311.

Andersen J, Stuhr-Hansen N, Zachariassen L, Toubro S, Hansen SMR, Eildal JNN, Bond AD, Bøgesø KP, Bang-Andersen B, Kristensen AS, Strømgaard K (2011) Molecular determinants for seletive recognition of antidepressants in the human serotonin and noreinephrine transporters. PNAS 108(29): 12137-42.

Kristensen AS, Andersen J, Jørgensen TN, Sørensen L, Eriksen J, Loland CJ, Strømgaard K, Gether U (2011) SLC6 neurotransmitter transporters: structure, function, and regulation. Pharmacological Reviews 63(3): 585-640.

Kristensen AS, Jenkins MA, Banke TG, Schousboe A, Makino Y, Johnson RC, Huganir R, and Traynelis SF (2011) Mechanism of CaMKII regulation of AMPA receptor gating. Nature Neuroscience 14(6):727-735.

Bach A, Eildal JNN, Stuhr-Hansen N, Deeskamp R, Gottschalk M, Pedersen SW, Kristensen AS, Strømgaard K. (2011). Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-asparate receptor interaction. Journal of Medicinal Chemistry 54(5):1333-46.

Barslund AF, Poulsen MH, Bach TB, Lucas S, Kristensen AS, Strømgaard K (2010) Solid-Phase Synthesis and Biological Evaluation of Joro Spider Toxin-4 from Nephila clavata. Journal of Natural Products 74(3): 483-6.

Frølund S, Bella A, Kristensen AS, Ziegler HL, Witt M, Olsen CA, Strømgaard K, Franzyk H, Jaroszewski JW (2010). Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists. Journal of Medicinal Chemistry 53(20): 7441-51.

Chi CN, Bach A, Gottschalk M, Kristensen AS, Strømgaard K, Jemth P (2010). Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example. Journal of Biological Chemistry 285(36): 28252-60.

Andersen J, Olsen L, Hansen KB, Taboureau O, Jørgensen FS, Jørgensen AM, Bang-Andersen B, Egebjerg J, Strømgaard K, Kristensen AS (2010). Mutational mapping and modeling of the binding site for (S)-Citalopram in the human serotonin transporter. Journal of Biological Chemistry 285(3):2051-63.

Bach A, Chi CN, Pang GF, Olsen L, Kristensen AS, Jemth P, and Strømgaard K (2009). Design and Synthesis of Highly Potent and Plasma-Stable Dimeric Inhibitors of the PSD-95/NMDA Receptor Interaction. Angewandte Chemie International 48(51):9685-9. 

Clausen RP, Naur P, Kristensen AS, Greenwood JR,  Strange M,  Bräuner-Osborne H,. Jensen AA, Nielsen AST, Ringgaard LM, Nielsen B, Pickering D, Brehm L, Gajhede M, Krogsgaard-Larsen P, Kastrup JS (2009). The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid: Structure-based modification, improved synthesis, and pharmacological and biostructural characterisation. Journal of Medicinal Chemistry 52(15):4911-22.

Gottschalk M, Bach A, Hansen JL, Krogsgaard-Larsen P, Kristensen AS, Strømgaard K (2009). Detecting protein-protein interactions in living cells: Development of a bioluminescence resonance energy transfer (BRET) assay to evaluate the PSD-95/NMDA receptor interaction. Neurochemistry Research 34(10):1729-37.

Andersen J, Kristensen AS, J, Bang-Andersen B, Strømgaard K (2009). Recent Advances in the Understanding of the Interaction of Antidepressant Drugs with Serotonin and Norepinephrine Transporters. Chemical Communications 25:3677-92.

Andersen J, Taboureau O, Hansen KB, Olsen L, Egebjerg J, Strømgaard K, Kristensen AS (2009). Location of the Antidepressant Binding Site in the Human Serotonin Transporter: Importance of Ser-438 in Recognition of Citalopram and Tricyclic Antidepressants. Journal of Biological Chemistry 284(15): 10276-10284.

Hansen KB, Naur P, Kurtkaya1 NI, Kristensen AS, Gajhede M, Kastrup JS, and Trayelis SF (2009). Modulation of the Ionotropic Glutamate-like Receptor δ2 by D-serine and Extracellular Calcium. Journal of Neuroscience 29(4):907-917.

Nelson JK, Frølund SU, Tikhonov D, Kristensen AS, and Strømgaard K (2009). Synthesis and Biological Activity of Argiotoxin-636 and Derivatives Provide Selective Antagonists for Ionotropic Glutamate Receptors. Angewandte Chemie International 48(51): 3087-3091.