Bent Halling-Sørensen

Scientific Career

Professor Institute of Pharmaceutics and Analytical Chemistry. The Danish University of Pharmaceutical Science, 2003
Associate prof. Institute of Analytical Chemistry. The Danish University of Pharmaceutical Science, 1998
Assistant prof. / Associate prof., Institute of Analytical and Pharmaceutical Chemistry, The Royal Danish School of Pharmacy, 1996
Visiting prof. Padua University, Italy, 1998
Assistant prof., Institute of Environmental Science and Ecology, and Institute of Environmental Science and Technology (IMT). The Technical University of Denmark, 1993
PhD. Student The Royal Danish School of Pharmacy, 1990
Research assistant, Institute for General Chemistry, The Royal Danish School of Pharmacy, 1989

Research Interests

Environmental analytical chemistry
Chemical toxicology
Antimicrobial agents and steroid hormone metabolisms

Research projects

Participating in the following major national or international projects:

1. SOUND - Molecular Tools for Sustainable Land Use
   http://www.igv.kvl.dk/projects/sound/
2. ERApharm - Environmental Risk Assessment of Pharmaceuticals SIXTH FRAMEWORK PROGRAMME PRIORITY 1.1.6.3
   Global Change and Ecosystems SPECIFIC TARGETED RESEARCH PROJECT http://www.erapharm.org/
3. Trainau - Training Risk assessment in the non-human antibiotic usage Marie Currie fellowship project
   http://www.trainau.dk/

Teaching

(Danish only)
AB-11-1 Toxicology / Occupational Health
A-317, Aquatic Environmental Chemistry
A28-2 Evaluation af Pharmacopoeia Substances

Supervision

Theses

Publications

Publications 2007 to present
Click on the headline to view list.

2001-2006
Lykkeberg AK, Cornett C, Halling-Sorensen B, et al.
Isolation and structural elucidation of tiamulin metabolites formed in liver microsomes of pigs 
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 42 (2): 223-231 SEP 18 2006
Agerso Y, Wulff G, Vaclavik E, et al.
Effect of tetracycline residues in pig manure slurry on tetracycline-resistant bacteria and resistance gene tet(M) in soil microcosms 
ENVIRONMENT INTERNATIONAL 32 (7): 876-882 SEP 2006
Soeborg T, Ganderup NC, Kristensen JH, et al.
Distribution of the UV filter 3-benzylidene camphor in rat following topical application 
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 834 (1-2): 117-121 APR 13 2006
Jacobsen AM, Halling-Sorensen B
Multi-component analysis of tetracyclines, sulfonamides and tylosin in swine manure by liquid chromatography-tandem mass spectrometry 
ANALYTICAL AND BIOANALYTICAL CHEMISTRY 384 (5): 1164-1174 MAR 2006 Soeborg T, Hansen SH, Halling-Sorensen B
Determination of bisphenol diglycidyl ethers in topical dosage forms 
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 40 (2): 322-330 FEB 13 2006
Andersen HR, Hansen M, Kjolholt J, et al.
Assessment of the importance of sorption for steroid estrogens removal during activated sludge treatment
CHEMOSPHERE 61 (1): 139-146 SEP 2005  
Sanderson H, Ingerslev F, Brain RA, et al.
Dissipation of oxytetracycline, chlortetracycline, tetracycline and doxycycline using HPLC-UV and LC/MS/MS under aquatic semi-field microcosm conditions 
CHEMOSPHERE 60 (5): 619-629 JUL 2005
Halling-Sorensen B, Jacobsen AM, Jensen J, et al.
Dissipation and effects of chlortetracycline and tylosin in two agricultural soils: A field-scale study in southern Denmark 
Environmental Toxicology and Chemistry 24 (4): 802-810 APR 2005
Halling-Sørensen B, Jacobsen A-M, Jensen J, Sengeløv G, Vaclavik E, Ingerslev:  Dissipation and Effects of Chlortetracycline and Tylosin in two Agricultural Soils - A Field-scale Study in Southern Denmark - Environ. Toxicol.
Chem Vol 24:, 4 p 802-10, 2005
Blackwell PA, Lützhøft HCH, Ma P, Halling-Sørensen B, Boxall ABA, Kay, P.:
Ultrasonic extraction of veterinary antibiotics from soils and pig slurry with SPE clean-up and LC-UV and fluorescence detection.
Talanta 64:1058-64, 2004
Vaclavik E, Halling-Sørensen B, Ingerslev F:
Evaluation of manometric respiration tests to assess the effects of veterinary antibiotics in soil.
Chemosphere 56:667-76, 2004
Andersen H, Siegrist H, Halling-Sørensen B, Ternes T.
Fate of estrogens in a municipal treatment plant. Environ. Sci.
Technol  (2003) Vol 37: 4021-4026, 2004
Rasmussen D, Winther-Nielsen M, Graham D, Halling-Sørensen B,:
Using laboratory experiments and computer models for assessing the potential risk of recycled waste materials - case studies.
In Tarek Kassim, THE HANDBOOK OF ENVIRONMENTAL CHEMISTRY - Water Pollution Series (SPRINGER-VERLAG), 2004
Boxall ABA, Kolpin DW, Halling-Sørensen B, Tolls J.:
Are Veterinary Medicines causing environmental Risk? Environ. Sci.
Technol  287-294, 2003
Blackwell P, Holten Lützhøft HC, Ma HP, Halling-Sørensen B, Boxall ABA, Kay, P.:
Fast and Robust simultaneous determination of three veterinary antibiotics in groundwater and surface water using tandem solid-phase extraction with high performance liquid chromatography-UV detection.
J. Chromatogr. A.Vol 1045:111-117
Andersen H.R, Petersen M, Holst-Jørgensen M. Nors Nielsen S, Halling-Sørensen B.: Different Estrogen Potencies of Parabenes in the MCF7 E-Screen Assay.
Submitted
Søeborg, T,  Ingerslev. I, Halling-Sørensen
Kinetics of the degradation of chlortetracycline and chlortetracycline degradation products in soil interstitial water.
Chemosphere 57:1515-24, 2004
Lykkeberg AK,  Sengeløv G,  Cornett C,  Tjørnelund J, Hansen SH, Halling-Sørensen B:
Isolation, structural elucidation and in vitro activity of 2-acetyl-2-decarboxamido-oxytetracycline against Environmental relevant Bacteria, Including Tetracycline-Resistant Bacteria.
J Pharm and Biomedical Analysis Vol 34: 559-567
Lykkeberg AK, Halling-Sørensen B, Cornett C, Tjørnelund T, Hansen SH:
Quantitative Analysis of Oxytetracycline and Oxytetracycline Impurities by LC-MS-MS.
J Pharm and Biomedical Analysis Vol 34: 325-332.
Jacobsen AM, Halling-Sørensen B, Ingerslev F, Hansen SH: 
Simultaneous extraction of tetracycline, macrolide and sulfonamide antibiotics from agricultural soils using presurrised liqiod extraction followed by soild-phase extraction and liqiod chromatography-tandem mass spectrometry.
J Chromatogr. A 1038:157-170, 2004
Sengeløv G, Halling-Sørensen B, Aarestrup FM: 
Susceptibility of E.coli and Enterococus feacium isolated from pigs and broilers to tetreacycline degradation products and distribution of tetracycline resistance determinants in E.coli from food animals.
Veterinary Microbiology vol 95:91-101, 2003
Ingerslev,F., Vaclavik, E., Halling-Sørensen, B.:
Pharmaceuticals and personal care products  - a source of endocrine disruption in the environment.
Pure and Applied Chemistry. Vol 75:1881-1893, 2003
Krogh KA, Halling-Sørensen B, Mogensen BB, Vejrup KV:
Environmental properties and effects of nonionic surfactant adjuvants in pesticides: a review.
Chemosphere 50:871-901, 2003
De Liguoro M, Cibin V, Capolongo F, Halling-Sørensen B, Montesissa C.
Use of oxytetracycline and tylosin in calf intensive farming: Evaluation of their transfer to manure and the amended soil.
Chemosphere 52:203-212, 2003
Halling-Sørensen, B., Lykkeberg A, Ingerslev F., Blackwell P., Tjørnelund J.: 
Characterisation of the abiotic degradation pathway of oxytetracycline in soil interstitial water using LC-MS-MS.
Chemosphere 50:1331-1342, 2003
Halling-Sørensen, B., Sengeløv G., Ingerslev F., Bogø Jensen L.:
Reduction of Antimicrbial Potencies of Oxytetracycline, Tylosin, Sulfadiazine, Streptomycin, Ciprofloxacin and Olaquindox due to Environmental Processes.
Arch. Environ. Contam. Toxicol. 44:7-16, 2003
Krogh KA, Vejrup KV, Mogensen BB, Halling-Sørensen B.:
LC-MS method to determine alcohol ethoxylates and alkylamine ethoxylate in soil interstitial water, ground water and surface water samples.
J. Chromatogr. A 957:45-57, 2002
Sengeløv G, Agersø Y, Halling-Sørensen B, Baloda SB, Jensen LB.: 
Bacterial antibiotic resistance levels in farmland as a result of treatment with pig slurry.  Environ. Int. 28: 587-95, 2003 
Loke ML, Jespersen S, Vreeken R, Halling-Sørensen B, Tjørnelund J.:
Determination of oxytetracycline and its degradation products by HPLC.MS-MS in manure containing anaerobic test systems.
J. Chromatogr. B. 783:11-23, 2003
Di Guardo A, Calamari D., Benfenati E.,  Halling-Sørensen, B. Zucatto E., Fanelli R.: Pharmaceuticals as Environmental Contaminats: Modelling Distribution of fate.  
In "Pharmaceuticals in the environment - Sources, fate, effects and risks". Springer ISBN no. 3-540-4167-8, 2001
Loke, ML, Tjørnelund J, Halling-Sørensen B:
Determination of the distribution coefficient (log kd) of oxytetracycline, tylosin, olaquindox and metronidazole in manure.
Chemosphere 48:351-361, 2002
Halling-Sørensen, B., Sengeløv G., Tjørnelund J.:
Toxicity of Tetracyclines and Tetracycline degradation products to environmental relevant bacteria including selected Tetracycline resistant bacteria.
Arch. Environ. Contam. Toxicol 42:263-271, 2002
Halling-Sørensen, B:
Inhibition of aerobic growth and nitrification of bacteria in sewage sludge by antibacterial agents
Arch. Environ. Contam. Toxicol 40:451-460, 2001 
Andersen, H.R. Wollenberger, L., Halling-Sørensen, B., and Kusk. K.O.:
Development of copopod nauplii to copepodites - A parameter for chronic toxicity including endocrine disrption.
Environ. Tox and Chem. Vol. 20(12) pp 2821-2829, 2001
Ingerslev F.,Toräng, L., Loke, M.L. Halling-Sørensen, B., and Nyholm, N:, (2001) Primary biodegradation of veterinary antibiotics in aerobic and anaerobic surface water simulation systems. 
Chemosphere Vol 44: 865-872, 2001
Ingerslev, F., and Halling-Sørensen, B.:
Biodegradability of metronidazole, olaqiondox, and tylosin, and formation of tylosin degradation products in aerobic soil/manure slurries.
Ecotox. and Env. Safety 48:311-320, 2001
Halling-Sørensen, B. Jensen, J,  Tjørnelund J. Montfors M.H.M.M:
Worst-case estimations of predicted environmental soil concentrations (PEC) of selected veterinary antibiotics and residues in Danish Agriculture. Chapter 13 pp 143-56
In "Pharmaceuticals in the environment - Sources, fate, effects and risks". Springer ISBN no. 3-540-4167-8, 2001