Birger Brodin Larsen

Scientific Career

Associate Professor at the Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutics, University of Copenhagen, 2002
Associate Research Professor at the Department of Pharmaceutics, the Royal Danish School of Pharmacy, 2000
Assistant Research Professor at the Department of Pharmaceutics, the Royal Danish School of Pharmacy, 1998
Assistant Research Professor at the August Krogh Institute, University of Copenhagen, 1995
PhD in Cellular Physiology, August Krogh Institute, University of Copenhagen, 1994

Research Interests

Biophysics of drug transport across biological barriers
Molecular characterisation of drug-transporting membrane proteins (molecular pharmacokinetics

Supervision

Theses in Danish
Theses in English

Publications

Publications 2007 - present
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2003-2006

Anderle, P.; Nielsen, C.U.; Pinsonneault, J.; Krog, P.L.; Brodin, B.; Sadée, W.
Genetic Variants of the Human Dipeptide Transporter PEPT1.
J Pharmacol Exp Ther (2006) 316(2):1-11
Vullo, D; Steffansen, B; Brodin, B; Supuran, C.T.; Scozzafava, A; Nielsen; C.U. Carbonic anhydrase inhibitors.Transepithelial transport of novel anticancer sulfonamide inhibitors of the cancer-associated isozyme CA IX is dependent on the p-gp efflux transporter
Bioorg. Med. Chem. (14), 2418-2427, 2006.
Bravo, S.A.; Nielsen, C.U.; Frokjaer, S.; Brodin, B.
Characterization of rPEPT2-Mediated Gly-Sar Transport Parameters in the Rat Kidney Proximal Tubule Cell Line SKPT-0193 cl. 2 Cultured in Basic Growth Media
Mol Pharm 2005; 2 (2): 98-108
Eriksson, A.H.; Elm, P.L.; Begtrup, M.; Brodin, B.; Nielsen, R.; Steffansen, B.
Pyrimidine and nucleoside gamma-esters of L-Glu-Sar: Synthesis, stability and interaction with hPEPT1
Eur J Pharm Sci 2005; 25: 145-154
Eriksson, A.H.; Elm, P.; Begtrup, M.; Nielsen, R.; Steffansen, B.; Brodin, B.
hPEPT1 Affinity and Translocation of Selected Gln-Sar and Glu-Sar Dipeptide Derivatives
Mol Pharm 2005; 2(3): 242-249
Foged, C.; Brodin, B.; Frokjaer, S.; Sundblad, A.
Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model.
Int J Pharm. 2005;298(2):315-22
Nielsen, C.U.; Våbenø, J.; Andersen, R.; Brodin, B.; Steffansen, B.
Recent advances in therapeutic application of Human Peptide Transporters.
Expert Opin Ther Patents, 2005; 15(2), 153 - 166.
Bravo, S.A.; Nielsen, C.U.; Amstrup, J.; Frokjaer, S.; Brodin, B.
Epidermal growth factor decreases PEPT2 transport capacity and expression in the rat kidney proximal tubule cell line SKPT0193 cl. 2.
Am J Physiol Renal Physiol (2004) 286; F385-F393
Bravo,S.A.; Nielsen,C.U.; Amstrup,J.; Froekjaer,S.; Brodin, B.
In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model.
European Journal of Pharmaceutical Sciences (2004) 21(1):77-86
Steffansen, B.; Nielsen, C.; Brodin, B.; Eriksson, A.E.; Andersen, A.; Frokjaer, S. Intestinal solute carriers: an overview on trends and strategies for improving oral drug absorption.
European Jourrnal of Pharmaceutical Sciences (2004) 21(1):3-16
Thomsen, A.E.; Fredrichsen, G.M.; Sørensen, A.H.; Andersen, R.; Nielsen, C.U.; Brodin, B.; Begtrup, M.; Frokjaer, S.; Steffansen, B.
Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: Affinity for hPepT1 in Caco-2 cells, drug release in aeqous media and in vitro metabolism.
J. Contr. Rel. (2003) 86: 279-292
Nielsen, C.U.; Amstrup, J.; Nielsen, R.; Steffansen, B.; Froekjaer, S.; Brodin, B.
Short term effects of EGF on peptide transport in a human intestinal cell line, Caco-2.
Acta Physiol. Scand. (2003) 178:139-148
Nielsen, C.U.; Brodin,B.
Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and pathophysiological conditions.
Current Drug Targets. (2003) 4:373-388