Ole J. Bjerrum

(MD, DMSc), served at the Medical Faculty, University of Copenhagen from 1969-1987. Further to this Ole J. Bjerrum has 14 years of industrial experience at Novo Nordisk, working as director first for a diagnostic unit then with various aspects of drug discovery and finally as liaison officer between the company and academia and national and international research organisations. In 2001, Professor in Pharmacology at the Danish University of Pharmaceutical Sciences. Now department of pharmacology and pharmacotherapy, Faculty of Health and Medical Sciences, University of Copenhagen. Scientifically Ole J. Bjerrum has been engaged in the analysis and characterisation of membrane receptors and transporters (thesis 1977). Lately, he has engaged himself in in vitro and in vivo pharmacology aspects of pain with a translational perspective utilizing the combination aspect of registrered drugs. Through his membership of EUFEPS, where he now is past-president, he has engaged in three workshops related to the problems of European drug development covered under the title New Safe Medicines Faster, which paved the way for the EU programme Innovative Medicines Initiative worth 2 billions Euro.

Research Area:

Translational pharmacology/medicine with focus on neuropathic pain. Patophysiological investigations through pharmacological interventions.

Background and aim:

Pain after nerve injury (neuropathic pain) appears infrequently among patients. Further the condition is difficult to treat. Preclinical and clinical experiments with analgesics have shown individual discrepancy in respons. This probably reflects patient variation in the activation of the pain provoking mechanisms of sensing, transduction and transmission. The aim of the project is through better knowledge of the patophysiological mechanisms to improve the individual treatment regime of patients suffering from chronic pain.

Methods

Spared Nerve Injury (SNI) models (SNI, SNL, CCI) in rats for neuropathic pain. Rat models for acute and inflammatory pain (Hot plate, test with formalin and complete Freund's adjuvant, Hargreaves plantar test. Pharmacodynamic pain assessment with von Frey filaments, pin prick Randa Solito.

Cell culturing of neurons from dorsal root ganglia (DRG). Fluorescent imaging af Ca⁺⁺ fluxes in cultured DRG neurons in presence of pharmacological active compounds. Immunostaining of cell markers of cultured neurons. Pharmacological characterisation of individual neurons in DRG cell cultures from naïve/injured/treated SNI, SNL rats.

Current projects

New treatment regimens for neuropathic pain tested on rat pain models. 

§        Effect of combination therapy of drugs acting on different targets of the pain transmission pathway inclusive PK/PD studies.

§        Effect of pharmacologic prophylaxis for the development of neuropathic pain.

Translational animal models to predict human behaviour to nerve lesions and pharmacologic treatment. The importance of species differences.

Molecular mechanisms behind the effect of the GABA_A agonist THIP and gabapentin on cultured neurons of afferent dorsal root ganglions from injured nerves.

Phase 1 dose escalation trials. An assessment of current and novel trial designs.

Combination therapies for treatment of neuropathic pain. Synergistic effect of gabapentin and donepezil in rats and man.

Modeling of combinatorial effect of analgesics.

Antinoceptive effect of ceftriaxone via modulation of glutamate transporters (GLT).

In vitro and in vivo characterization of GLT's.

Characterization of the GTP cyclohydrolase I (GCH1) gene effect on pain perception in mouse and man.

Research group per 1st January 2012

Guest professor: Georgi Gegelashvili

PhD students:
Anna Basnet
Arafat Nasser
Pernille Kristensen

Master students:
Kamilla Frederiksen
Charlotte Jensen
Bodil Jensen

Ole Jannik Bjerrum

Born 1944.03.20 in Copenhagen, Denmark

 

1969          M.D. (Cand. med.), University of Copenhagen

1978          Doctor of Medical Sciences (DMSc/dr.med.), University of Copenhagen

1988-98     Adjunct professor, Dept. Biochemistry & Nutrition, Technical University of DK

1999-2004 Adjunct professor, Faculty of Health, University of Southern Denmark

2001          Professor, Faculty of pharmaceutical Sciences, University of Copenhagen

 

Appointments

1969-70     Internship at University Hospital of Copenhagen

1970-71     Research fellow at Institute of Biochemistry, University of Uppsala, Sweden

1971-74     Assistant professor, Protein Laboratory, University of Copenhagen

1974-87     Associate professor, Protein Laboratory, University of Copenhagen

1980-81     Visiting professor, Dept. of Biochemistry & Molecular Biology,
                 Northwestern University, Ill, USA

1982-87    Director, Protein Laboratory, University of Copenhagen

1987-91     Director, Biolabs and Immunotechnology, Novo Nordisk A/S,
                 Bagsvaerd.

1991-96     Principal Research Scientist, Assay and Cell Technology,
                 Novo Nordisk A/S

1996-01     Research Counsellor, Corporate Research Affairs, Novo Nordisk A/S

2001-         Professor of pharmacology, Faculty Pharmaceutical Sciences,
                 University Copenhagen

2006          Visiting professor, pharmaceutical safety science, University of Vienna

 

Publications, lectures, symposia and congresses

1968-         Author of 150 publications
                (104 are original papers in int. refereed journals)

1983          Editor of “Electroimmunochemical Analysis of Membrane proteins”,
                481 pp, Elsevier

1988          Editor with N.H. Heegaard of
                 “Handbook of Immunoblotting of Proteins”,
                 Vols. I, II, 214 and 265 pp  CRC Press

1976-         Invited lecturer at 42 international symposia and workshops

1988          Co-organizer of 6th Int. Congress of Electrophoresis

1991          Organizer and chair of Scandinavian Electrophoresis Society’s 3rd
                 Congress

1996          Co-organizer of EC Meeting for Biotech Trainees:
                 “Industrial Connections to Biotech”

1998          Co-organizer of EC First Conference of the Biotechnology
                 & Finance Forum

2000          Co-organizer (chair) of EU/EUFEPS/EFPIA Workshop:
                 New Safe Medicines    Faster

2002          Organizer (chair) EUFEPS Conference: Biotech Medicines

2002          Organizer (chair) EU/EUFEPS Symposium: Afternoon Specials –
                 New Safe Medicine Faster

2003          Co-organizer (chair) of EUFEPS/EUREKA Workshop:
                 New Safe Medicines Faster

2004-07     Organizer EUFEPS Workshop: Safety Science

2004          Co-organizer EUFEPS Congress: New Safe Medicines.
                 Towards Mechanistic Prediction

2005          Organizer EU/EUFEPS Workshop on Innovative Medicines

2006          Coorganizer of EUFEPS Conference on 
                 Pharmaceutical Safety Science, Austrian Science Academy

2006-07     Co-organizer EUFEPS/BioSim Conference Systems Biology.

2009          Member of European education team for IMI:
                 SafeSciMET granted with 3 mill Euro

 

Areas of research expertise

Pain in vitro/ in vivo pharmacology; drug discovery and pharmaceutical safety science; cell biology; protein chemistry; immunotechnology.

 

 

Awards

2006 Danish Academy of Natural Sciences’ Industry prize. Gold medal

2007 Pharmaceutical Sciences World Conferences Research Achievement Award

 

Offices & Memberships

1976-87     Member, Editorial Board, J. Biochem. Biophys. Methods

1982-88     Member of the Board, Danish Biochemical Society (chairman 1984-86)

1983          Fellow, Danish Academy of Natural Sciences

1985-90     Member, Editorial Board, Electrophoresis

1986-91     Council member, International Electrophoresis Society

1986-93     Member of the Board, Scandinavian Electrophoresis Society 
                 (chairman 1989-93)

1988-98     Member, Editorial Board, Appl. Theoret. Electrophoresis

1991          Fellow, Danish Academy of Technical Sciences

1992-98     Member of the Board, 
                 Danish Society Theoret. & Applied Medicine(chairman 1996-97)

1993-99     Appointed member, Danish Medical Research Council

1993-94     Member of the Board of Directors, PNA Diagnostics A/S

1994-97     Member, National Biotechnology Committee,
                 Ministry of Research, DK

1994-98     Danish delegate: EU 4^th Framework Programme
                 Committee on Biotechnology, Brussels

1996-01     Member, Steering Committee for Center of Proteome Analysis,
                 University Odense

1997-02     Chairman, Danish Association of Physicians in Private Employment

1997-98     Danish delegate, European Science and Technology Assembly
                 (ESTA)

1998-01     Member of Committee on Industrial Relations,
                 Eur. Fed. Pharm. Sciences  (EUFEPS)

1999-03     Danish delegate: EU 5th Framework Programme Manag.
                 Committee on Quality of Life

1999-02     Member Governing board,
                 Eur. Assoc. for Promotion of Sci. & Tech.(Euroscience)

1999-07     Member of Executive Committee, President 2003-05,
                 Eur. Fed. Pharm. Sciences (EUFEPS)

2002-05     Member of Executive Committee of European Ethics Network (EEN)

2003-         Member, Editional Board, Eur.J.Pharm.Sci

2005-08     Danish delegate. EU Memberstate group, Technological Platform,
                 Innovative Medicine IMI.

2008-         Vicechairman EUFEPS Safety Sciences Network

2010-         Fellow of European Pharmaceutical Sciences Senate 

2011          Member of Editorial Board, Scand. J. Pain

Ole J. Bjerrum: Publikationer 2008 til Jan 2012

163. Buoen, C., Bjerrum, O.J., Thomsen, M. Assessment of First-in-Man safety laboratory data to evaluate the hospitalisation effect in phase 1 studies in healthy subjects. 2012 (In preparation)

 

162. Jacobsen, N.W., Heegard, A.M., Hansen, M., Björklund, E., Kramer-Birkved, F., Bjerrum, O.J., Halling-Sørensen, B. The effects of valproic acid on the steroid hormone balance in male rats. In PhD thesis N.W. Jacobsen, FARMA, University of Copenhagen, Denmark. 2011

 

161. Basnet, A., Hartvig, P.H., Bjerrum, O.J., Kristensen, K. Population pharmacodynamic models for gabapentin, donepezil and venlafaxine and evaluation of drug combination effects in rats with spared nerve injury. J. Pharmacokinetic and Dynamic 2011 (submitted)

 

160. Basnet, A., Butler, S., Hartvig, P.H., Margereta, B., Gordh E.T., Bjerrum O.J. Gabapentin alone and in combination with donepezil or venlafaxine in post-traumatic neuropathic pain. Clin. J. Pain 2011 (submitted)

 

159. Nasser, A., Bjerrum, O.J., Heegaard, A.M., Møller, A.T., Larsen, M., Dalbøge, L.S., Dupont, E., Jensen, T.S., Møller, L.B. Differential pain phenotypes of hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in acute, inflammatory and neuropathic pain models. Pain 2011 (submitted)

 

158. Christensen, S.T, Bjerrum O.J. Detection of Adverse Drug Reactions among ordinary users of liraglutide on the occasion of drug dispensing in the Community Pharmacy Setting. British J. Clin. Pharm. 2011 (submitted)

 

157. Nasser, A., Bjerrum, O.J., Heegaard, A.M., Møller, A.T., Larsen, M., Dalbøge, L.S., Dupont, E., Jensen, T.S., Møller, L.B. Reduced inflammatory pain hypersensitivity and intact acute pain in the hph-1 mouse mutant deficient in GTP cyclohydrolase 1. Pain 2012 (submitted)

 

156. Honoré, P.H., Basnet A., Kristensen P., Andersen L.M, Neustrup S., Møllgaard P., Eljaja L., Bjerrum O.J. Predictive validity of pharmacologic interventions in animal models of neuropathic pain. Scand. J. Pain 2011; 2: 178-184

 

155. Honoré, P.H., Basnet A., Eljaja L.,  Kristensen P., Andersen L.M, Neustrup S., Møllgaard P., Bjerrum O.J. Neuropathic pain models the in development of analgesic drugs. Scand. J. Pain 2011; 2: 172-177

 

154. Bjerrum, O.J. Excellence in education and training advances competitiveness of the pharmaceutical industry in Europe. Eur. J. Pharm. Sci. 2011. 44, (1-2), 174-175

 

153. Richner, M., Bjerrum O.J., Nykjaer, A., Vaegter C.B. The Spared Nerve Injury (SNI) model of induced mechanical allodynia in mice. J. of Visualized Experiments 2011; 54. www.jove.com/details.php, doi:10.3791/3092

 

152. Eljaja, L., Bjerrum O.J., Hartvig, P.H., Abrahamsen B. Effects of the excitatory amino acid transporter subtype 2 (EAAT-2) inducer ceftriaxone on different pain modalities in rat

Scand. J. Pain 2011; 2: 132-136

151. Christensen, S.T., Søndergaard, B., Hartvig, P.H. and Bjerrum, O.J.
Pharmacy student driven detection of adverse drug reactions in the community pharmacy setting
Pharmacoepidemiology and Drug Safety 2011; 20: 399-404

 

150. Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Houston, B., Oosterhuis, B., Bjerrum O.J., Grynkiewicz, G., Rowland, M. and Garner C. Comparative pharmacokinetics between a microdose and therapeutic dose for paracetamol (acetaminophen), Phenobarbital, sumatriptan, propafenone and clarithromysin in human volunteers. Eur. J. Pharm. Sci. 2011;43: 141-150.

 

149. Bjerrum, O.J. and Linden, H. Chapter: European New Safe and Innovative Medicines Initiatives History and Progress to day in Translational Medicine and Drug Discover in Translational Medicine and Drug Discovery,. Ed. Littman, B.H. and Krishna, R. 2011 Cambridge University Press, pp. 265-288.

 

148. Folkesson, A. Hartvig Honoré P, Munkholm Andersen L, Kristensen P, Bjerrum OJ. Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies. J Neural Transm 2010;117:1377-1385.

 

147. Folkesson, A., Honoré, P.H., and Bjerrum, O.J. Co-administered gabapentin and venlafaxine in nerve injured rats: Effects on mechanical hypersensitivities, motor function and pharmacometrics. Scand. J. Pain, 2010, 91-97

 

146. Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R., Gesson, C., Houston, B., Oosterhuis, B., Bjerrum, O.J., Rowland, M., Garner, C. Pharmacokinetics of fexofenadine: Evaluation of a microdose and assessment of absolute oral bioavailability. Eur. J. Pharm. Sci. 40, 2010, 125-131.

 

145. Crommelin, D.J.A. and Bjerrum, O.J. The EUFEPS workshop on institutional Peer Review “The Ultimate Tool to Advance the Pharmaceutical Sciences?” A Continuing story. Eur. J. Pharm. Sci. 2008, 35, 361-364

 

144. Bjerrum, O.J. and Heegaard, N.H.H. Western Blotting Immunoblotting in Encyclopedia of Life Sciences ELS, John Wiley & Sons Ltd 2008 Chichester , A. 995 pp 1–15

 

143. Hald, A., Ding, M., Egerod, K., Hansen, R.R., Konradsen, D., Jørgensen, S.G., Atalay, B., Nasser, A., Bjerrum, O.J. and Heegaard, A.-M. Differential effects of repeated low dose treatment with the cannabinoid agonist WIN 55, 212-2 in experimental models of bone cancer pain and neuropathic pain.
Pharmacol. Biochem. Behav. 2008, 91, 38-46

 

142. Bjerrum, O.J. Current Status of Pharmaceutical Innovation in the EU in Proceedings of Pharmaceutical Innovation: A New R&D Strategy in EU 19/20. Infarmed 2008, pp 11-12

www.infarmed.pt

 

1. Scientific publications

1.1.A Articles in peer-review scientific publications

Richner, M., Bjerrum O.J., Nykjaer, A., Vaegter C.B. The Spared Nerve Injury (SNI) model of induced mechanical allodynia in mice. J. of Visualized Experiments 2011; 54. www.jove.com/details.php, doi:10.3791/3092

Eljaja, L., Bjerrum O.J., Hartvig, P.H., Abrahamsen B. Effects of the excitatory amino acid transporter subtype 2 (EAAT-2) inducer ceftriaxone on different pain modalities in rat. Scand. J. Pain 2011; 2: 132-136

Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Houston, B., Oosterhuis, B., Bjerrum O.J., Grynkiewicz, G., Rowland, M. and Garner C. Comparative pharmacokinetics between a microdose and therapeutic dose for paracetamol (acetaminophen), Phenobarbital, sumatriptan, propafenone and clarithromysin in human volunteers. Eur. J. Pharm. Sci. 2011;43: 141-150.

Christensen, S.T., Søndergaard, B., Hartvig, P.H. and Bjerrum, O.J. Pharmacy student driven detection of adverse drug reactions in the community pharmacy setting. Pharmacoepidemiology and Drug Safety 2011; 20: 399-404

Honoré, P.H., Basnet A., Kristensen P., Andersen L.M, Neustrup S., Møllgaard P., Eljaja L., Bjerrum O.J. Predictive validity of pharmacologic interventions in animal models of neuropathic pain. Scand. J. Pain 2011; 2: 178-184

Honoré, P.H., Basnet A., Eljaja L.,  Kristensen P., Andersen L.M, Neustrup S., Møllgaard P., Bjerrum O.J. Neuropathic pain models the in development of analgesic drugs. Scand. J. Pain 2011; 2: 172-177

Nasser, A., Bjerrum, O.J., Heegaard, A.M., Møller, A.T., Larsen, M., Dalbøge, L.S., Dupont, E., Jensen, T.S., Møller, L.B. Differential pain phenotypes of hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in acute, inflammatory and neuropathic pain models. Pain. 2011 (submitted)

Christensen, S.T. Bjerrum, O.J. Detection of Adverse Drug Reactions among ordinary users of liraglutide on the occasion of drug dispensing in the Community Pharmacy Setting. Int. J. Patient Safety. 2011 (submitted)

Basnet, A., Butler, S., Hartvig, P.H., Margereta, B., Gordh E.T., Bjerrum O.J. Gabapentin alone and in combination with donepezil or venlafaxine in post-traumatic neuropathic pain. Clin. J. Pain. 2011 (submitted)

Basnet, A., Hartvig, P.H., Bjerrum, O.J., Kristensen, K. Population pharmacodynamic models for gabapentin, donepezil and venlafaxine and evaluation of drug combination effects in rats with spared nerve injury. J. Pharmacokinetic and Dynamic. 2011 (submitted)

Jacobsen, N.W., Heegard, A.M., Hansen, M., Björklund, E., Kramer-Birkved, F., Bjerrum, O.J., Halling-Sørensen, B. The effects of valproic acid on the steroid hormone balance in male rats. PhD thesis NW Jacobsen. 2011

Buoen, C., Bjerrum, O.J., Thomsen, M. Assessment of First-in-Man safety laboratory data to evaluate the hospitalisation effect in phase 1 studies in healthy subjects. 2012 (In preparation)

1.1.D Contribution to Scientific books

Bjerrum, O.J. and Linden, H. Chapter: European New Safe and Innovative Medicines Initiatives History and Progress to day in Translational Medicine and Drug Discover in Translational Medicine and Drug Discovery,. Ed. Littman, B.H. and Krishna, R. 2011 Cambridge University Press, pp. 265-288.

1.2     Reviews, editorial commentary/debate

Bjerrum, O.J. Excellence in education and training advances competitiveness of the pharmaceutical industry in Europe. Eur. J. Pharm. Sci. 2011;44:174-175

1.3 Conference contributions

1.3.A Conference contributions: articles, papers – not peer reviewed

Boonen H.C and Bjerrum O.J. Position Paper: Systems Pharmacology, presented at PharmSciFair, Prague, June 2011.

1.3.B Conference contributions poster, with published abstract

Eljaja, L., Honoré, P.H., Nejadi, A., Abrahamsen, B and Bjerrum, O.J.

Ceftriaxone, an EAAT-2 transporter inducer, shows antinociceptive effects in acute and neuropathic pain models. Scandinavian Association for the Study of Pain Annual Meeting, Uppsala, May 2011. Published in Scand. J. Pain (2011)

Nasser, A., Bjerrum, O.J., Heegaard A.M, Møller, L.B. The hph-1 mouse with inherited deficiency in GTP cyclohydrolase 1 show reduced inflammatory pain behavior. Scandinavian Association for the study of pain Annual Meeting, Uppsala, May 2011. Published in Scand. J. Pain 2011. Received Poster Prize.

1.3.C Conference contributions: poster, abstract

Kristensen, P.K., Frederiksen, K.K., Abrahamsen, B., Honoré, P.H., Bjerrum, O.J. Beta-lactam antibiotic as dose dependent analgesic treatment of neuropathic pain. 5^th Share Symposium, University of Copenhagen, November 6^th 2011.

Basnet, A with O.J. Bjerrum and Per H. Honoré as supervisor. Population modelling and simulation of response – time profiles for characterization of drug combination effect in a rat model of neuropathic pain. 5^th Share Symposium, University of Copenhagen, November 6^th 2011.

Boonen, H.C.M. Bjerrum, O.J. Systems Pharmacology from an Academic Perspective. PharmSciFair, Prague, June 2011.

Eljaja, L. Bjerrum, O.J., Honoré, P.H., Nejadi, A. and Abrahamsen, B. Decrease in nocifensive behaviour in rats after treatment with the EAAT-2 transporter inducer, ceftriaxone, PharmSciFair, Prague, June 2011.

Folkesson, A., Honoré, P.H., Bjerrum, O.J., Kristensen, K. Population pharmacodynamic modeling and simulation as a method to characterize drug combination effects in a rat model of neuropathic pain. PharmSciFair, Prague, June 2011.

Nasser, A., Bjerrum O.J., Heegaard A.M., Møller L.B. The hph-1 mouse mutant deficient in tetrahydrobiopterin show reduced acute and chronic inflammatory pain. Forskningens dag, FARMA, January 2011.

Folkesson, A., Honoré, P.H., Bjerrum, O.J., Kristensen, K. Characterization of drug combination effects in a rat model of neuropathic pain by population modelling and simulation of response-time profiles. 3^rd Annual Pharmacology meeting, University of Southern Denmark, January 2011.

Honoré P.H., Bjerrum O.J., Lund T.M., Ingwersen S.H., Thygesen P., Kristensen K., Larsen F., Angelo H.R., Development of Quantitative Pharmacology Pharmacometrics in Denmark. 3^rd Annual Pharmacology Meeting, University of Southern Denmark, Odense Denmark, January 2011.

Kristensen, P., Andersen, L.M., Folkesson, A., Hartvig, P.H., Bjerrum, O.J. Combination therapy for neuropathic pain: Donepezil improves gabapentins antinoceptive effect in SNI rats. 3^rd Annual Pharmacology Meeting, Odense, January 2011.

1.6 Further research contribution

1.6.A Patents

Nykjær A., Vægter, C., Bjerrum O.J.

Modulation of the TRPV: VPS10P-Domain Receptor System for the Treatment of Pain

Date of DK filing 24.06.09. EU application published February 2011

Application No./Patent No.: 09768854.3 – 2107 – PCT/DK2009050143

 

2. Communication publications

2.1.A Article in periodical/magazine

Bjerrum O.J. Contributed to: Redhair persons react differently to pain. Hoffman, T. Ed. www.videnskab.dk

2.1.E Contribution to research communicating books/antologies/reports

Contributed to IMI Handbook of SafeSciMET courses, www.safescimet.eu, Leiden, March 2011

 

3. Education publications

3.2 Compendium/lecture notes

Bjerrum, O.J., Course notes for MIND course. Drug Discovery and Development, Forlaget FARMA. January 2011

Bjerrum O.J. and Heegard A.M. Course notes for MIND course. Pharmacology, Forlaget FARMA, May 2011.

Bjerrum O.J. and Hartvig P.H.Course notes for MIND course. Clincal Pharmacology and Biostatistics, Forlaget FARMA, October 2011.

Bjerrum, O.J. New Safe Medicines Faster Initiative. EUFEPS Yearbook 20^th Aniversary 2011, forlag XX, ISBN

Bjerrum, O.J. Safety Science Intiative, EUFEPS Yearbook 20^th Aniversary 2011, forlag XX, ISBN

 

3.3 Contribution to textbooks/antologies

3.4 Sound and picture: video

Richner, M., Bjerrum O.J., Nykjaer, A., Vaegter C.B. The Spared Nerve Injury (SNI) model of induced mechanical allodynia in mice. J. of Visualized Experiments 2011; 54. www.jove.com/details.php, doi:10.3791/3092

3.5 Other educational contributions

Bjerrum, O.J., Møller, E.M., Steffansen, B., Helboe, P., Position Paper: Regulatory affairs, FARMA, May 2011.

Honoré, P.H., Nasser, A., Bjerrum O.J. Neuropathic pain models in animal pharmacology studies. Manual to ULLA Summerschool, Parma, Italy, July 2011.

 

4. Oral

4.1 Lectures with published abstract

Eljaja, L., Abrahamsen, B., Honoré P.H., Bjerrum, O.J., Alleviation of Nociception in Rats by treatment with Ceftriaxone, a β-Lactam that Promote Expression of the Excitatory Amino Acid Transporter 2., 19. January 2011, University of Southern Denmark, Odense Denmark.

4.2 Lectures (after invitation)

Bjerrum, O.J. Experimental measures leading to new pharmacological treatment of chronic pain. Educational Service, The Central Administration, University of Copenhagen, 28^th October 2011.

Bjerrum, O.J. Translational Pain Research – Pharmacist role. SafeSciMET IMI course 2.2 Regulatory requirement and guidelines, Faculty of Pharmacy, University of Lisbon, September 2011.

Bjerrum O.J, Spindler P., Lima B. Animal-human correlation at SafeSciMET IMI course 2.2 Regulatory requirement and guidelines, Faculty of Pharmacy, University of Lisbon, September 2011.

Bjerrum, O.J. Setting the biomarker scene at DRA Summer Conference, Helsingør August 2011.

Bjerrum, O.J. and Newall, D. Gained knowledge from Drug Discovery and Development Course 1.1 at SafeSciMET Harmonization meeting, Konstanz February 2011.

Bjerrum, O.J. and Kornerup, A. Status on Course 3.1 Laboratory animals, alternatives and ethics at SafeSciMET Harmonization meeting, Konstanz February 2011.

Bjerrum, O.J. Pharmacovigilance in the Community pharmacy setting. Best Practice in Phase IV Clinical & Observational Research 4^th Annual conference, London, October 2011.

Bjerrum O.J. Strengthening Non-clinical Safety Science through education and training. SafeSciMET IMI course 2.2 Regulatory requirement and guidelines, Lisbon September 2011.

 

4.3 Panel contributions

O. J. Bjerrum. Panel Contribution to Panorama Presentation and Discussion on “Access to Medicinal Products in Europe”: Innovation and Healthcare. PharmSciFair, Prague, June 2011.

 

5. Organization of scientific arrangements

5.1 Organization of external scientific arrangements

Co-chairman of PharmSciFair EUFEPS session: Model Based Drug Development through Systems Pharmacology, Prague, 2011, June 16.

Co-organizer and Chairman of session Modelbased Drug Development through Systems Pharmacology on PharmSciFair 2011, Prague, June 2011.

Co-organizer of Hot Topics in Safety Sciences: changes in Medicines Development and Safety demands, EUFEPS Network Conference, Vienna, May 2011.

Scientific and Planning Commiteee and Programme Advisors of Hot Topics in Safety Sciences: changes in Medicines Development and Safety demands, EUFEPS Network Conference, Vienna, May 2011.

 

5.2 Organization of FARMA arrangements

Co-organizer Drug Research Academy Summer School, Helsingoer, August 2011

Organizer of 5^th Share Conference on Session Systems Pharmacology at November 2011

Co-organizer with Per Hartvig. DRA Minisymposium: Pharmacometrics in clinical trial designs, FARMA, November 2011.

Co-organizer with Per Hartvig. DRA Minisymposium: New Horizons of Chronic Pain, FARMA, November 2011.

7. Refereeing

Pharmacology and Toxicology, Eur. J. Pharm. Sci. (x2)

From December 2011 Pharmacological Reviews

Editorial Board of Scand. J. Pain. member from August 2011

Invited as Editorial Board Member for Journal of Clinical Toxicology 2011.

Invited as Editorial Board Member for Pharmacoepidemiology & Drug Safety, August 2011.

 

8. Supervision

Master thesis MIND-students Berit Nautrup Andersen, Nycomed. Evaluation of Benefit-risk assessment in European Risk Management Plans.

Master thesis Bodil Kirstine Randerson Jensen. Afprøvning af nye analgetiske lægemidler til behandling af neuropatisk smerte. 2011. Co-supervisor.

Master thesis Charlotte Jensen. Afprøvning af nye analgetiske lægemidler til behandling af neuropatisk smerte. September 2011

Master thesis Kamilla Kjær Frederiksen. Combination therapy with ceftriaxone and established drugs of neuropathic pain in rats, January 2012.

Master thesis Louise Rosendahl. Inflammation og Neurodegeneration i musemodel. Neurosearch Co-supervisor Frederik Rode. 2011

Master thesis Bayati-Moqadam Z. Investigation of covalent binding of reactive drug metabolites to protein. Lundbeck Co-supervisor L. Dahlgaard. February 2011

Master thesis Evidsen Lund, T. and Borsdal, J. Distanceledelse in the pharmaceutical industry. Lundbeck 2010. Co-supervisor.

Ph.D. student. Folkesson, A. Combination therapy for alleviating pain. Co-supervisor Per Hartvig. FARMA 2012

Ph.D. student. Nasser, A. Translational study of genetics of pain. Effect of the GCM-1 gene. Co-supervisor Lisbeth Birk Møller. FARMA 2012

Ph.D student Kristensen, P. Beta-lactam antibiotics as analgesic treatment paradigm of neuropathic pain in rats and humans with co-supervisor Per Hartvig Honoré. FARMA 2014

Ph.D student. Co-supervisor for Ghorbani, M.L.M. with Sheykhzade, M. as main supervisor, Cardiac sensory nerve function in two animal models of diabetes. FARMA 2009

Ph.D student.Co-supervisor for Jacobsen, N.W. with Halling, B. as main supervisor, Characterization of hormone disturbing effects in children caused by medicines. FARMA 2011

Ph.D student Co-supervisor for Denninger, K. with Anderson, Å. as main supervisor, Evaluation of novel in vivo pharmacological models for psoriatic arthritis, FARMA 2012

Ph.D student Co-supervisor for Mikkel with Per Hatvig Honoré, FARMA 2011.

Censor at IMI-EU SafeSciMET Master Courses in Safety Science 2011-

 

9. Assessments

Monitor of Clinical study of Combination treatment of dannorubicin, cytarabin and etoposid of acute myeloid leukaemia principal investigator Hartvig, P.H., Rigshospitalet 2009-

 

10. Other activities

Guest professor at Department of Pharmacology, University of Lisboa, Faculty of Pharmacy in the period 15^th September to 1^st October 2011

Elected representative for EUFEPS Individual Membership, since 2007

Fellow of Academy of Natural Sciences since 1979

Fellow of Academy of Technical Sciences since 1995

Member of Biblioteksudvalget, FARMA, since January 2009

Member of Editorial Board Eur. J. Pharm. Sci. since 2001

Member of Editorial Board Scand. J. Pain since 2011

Member of Study Board for Masters, FARMA since 2003

Member of Steering Group for Drug Research Academy since 2005

Vicechairman of EUFEPS Safety Science Network, since 2009

Chairman for EUFEPS Committee on New Safe Medicines Faster Award since 2002

Chairman for Danmarks Naturvidenskabelige Akademis komité for DNA’s industripris since 2009-2010

Chairman at 3^rd Annual Meeting, 19 January 2011, Danish Society for Pharmacology, University of Southern Denmark, Odense.

Chairman at 4^th Share meeting, November 2011

 

11. Funding

SafeSciMET teaching fee 80.000 DKK

Listbeth B. Møller grant from Lundbeckfonden for post doc study for Arafat Nasser 1.4 mio.

Grant for 6 month guest professorship for Professor Georgi Gegelashvili 560.000