Camilla Foged

Scientific Career

Post.Doc at the Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2007
Assistant Research Professor at the Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2003
Research Assistant at the Department of Pharmaceutics, the Danish University of Pharmaceutical Sciences, 2003
PhD-student at the Department of Pharmaceutics, the Royal Danish School of Pharmacy, 1999

Research Interests

Targeted delivery of drugs to specific sites in the body is highly desired for many types of drugs associated with toxicity, high costs of production and serious side effects.
For biomacromolecules with intracellular sites of action such as oligonucleotides, plasmids and vaccines, targeted delivery across membrane barriers to the correct intracellular compartment is one of the key and largely unsolved problems in drug delivery today.
Research interests of CFO deal with lipid- and polymer based colloidal carriers for delivery of small interfering RNA (siRNA) and vaccines using various approaches for targeting and membrane destabilization such as cell penetrating peptides (CPPs).
Focus is directed towards a mechanistic understanding of the interaction between the colloidal drug carrier system and cellular membranes.
Furthermore, addressing stability of highly labile biomacromolecules is a major research area.
The carrier systems are designed for systemic administration, where the carriers can target inflammatory or cancer tissue passively via the enhanced permeability and retention (EPR) effect, or for local administration to tissues such as lungs and joints.
For vaccines, a major interest is the development of antigen delivery systems that can target dendritic cells and modulate their immuno-activating capacities in the desired direction.

Research Projects

• TARGETED IN VIVO KNOCK-DOWN OF SMALL NUCELIC ACIDS (http://www.sirna.dk)
• Long-circulating Liposomes for sPLA2 triggered Release of siRNA in Inflamed Tissue (arthritis)
• Cell Penetrating Peptides for siRNA Delivery
• Stability of siRNA and interactions with plasma proteins
• Lung Surfactant (HL10) as Delivery System for siRNA
• Spray-dried Polymeric Micro/Nanoparticles for Pulmonary Delivery of siRNA
• Targeting of Drug-loaded Virus Particles
• MEDITRANS: Targeted Delivery of Nanomedicines (http://www.meditrans-ip.net/), EU FP6 Integrated Project
• Optimization and characterization of adjuvant formulations based on cationic liposomes and immunomodulating compounds (collaboration with Statens Serum Institut)
• Cationic nanoparticles – a customisable adjuvant system (collaboration with Statens Serum Institut and other partners, sponsored by the Danish National Advanced Technology Foundation)
• Human dendritic cells as vaccination vehicles: Studies of antigen uptake and interaction with T-cells (collaboration with Karolinska University Hospital
• Encapsulation and controlled release of bioactive molecules (BioEnCap, sponsored by The Danish Agency for Science, Technology and Innovation

Teaching

F23-1: Lægemiddelformulering
F322: Videregående lægemiddelformulering
Bachelor's Project in Pharmacy (F24-3)
Introductory Pharmaceutical Course (T21-1)

PhD courses
Drug delivery (ph.d.-course)
Formulation strategies for maximizing the exposure of drug candidates in preclinical and clinical research, Ph.D.-course.
Biological Membranes, Drug Targets and Absorption Barriers, Ph.D.-course.

Supervision

Supervision of Ph.D.-, Master-, Scholar- and ERASMUS-students
Theses in Danish
Theses in English

Publications

Publications 
Click on the headline to see list in CURIS

Ph.D dissertation

Foged, C.
Human Dendritic Cells: Cell Culture Models for Studies of Particulate Antigen Formulations in vitro.
October 2003. The Danish University of Pharmaceutical Sciences.