Welcome to the Chemical Biology Group
About the ChemBiol group
The Chemical Biology group was founded in 2006 at the Dept. of Medicinal Chemistry, and consists of around 20 people; typically with a background in either medicinal or synthetic chemistry, pharmaceutical sciences, biotechnology or molecular biology.
The ChemBiol group anno 2010 in Falsterbo, Sweeden, during the annual lab retreat.
Our research
While several definitions exist for Chemical Biology as a scientific discipline, our intepretation is the use of chemistry as an integrated tool to the study and manipulation of biological systems.
We are interested in applying chemical methodlogies to study molecular aspects of the communication processes between nerve cells. Specifically, we focus on understanding the molecular function and structure of receptor and transporter proteins that are responsible of detecting and removing neurotransmitters from synapses, the sites of nerve cell communication in the brain.
Our experimental approaches involves combining chemical methodlogies such as synthetic organic chemistry and peptide synthesis with molecular biology and biochemical techniques to manipulate receptor and transporter proteins and to synthesize ligands that can modulate these proteins.
The background and status of our current research as well as description of some of our favorite methodologies are presented in the Current Research and Technology section.
Recently pusblished journal papers from the ChemBiol group
Andersen et al. (2011)
Molecular determinants for seletive recognition of antidepressants in the human serotonin and noreinephrine transporters.
PNAS 108(29):12137-42.
In this paper we describe how SSRI and NRI antidepressants distuinguish between the human serotonin and norepinephrine transporters.
Kristensen et al (2011)
Mechanism of CaMKII regulation of AMPA receptor gating.
Nature Neuroscience 14(6):727-735
This paper describes the molecular mechanism by which the signalling strentgh of AMPA receptors can be controlled by the enzyme CaMKII.
Kristensen et al (2011)
SLC6 neurotransmitter transporters: structure, function, and regulation.
Pharmacological Reviews 63(3): 585-640.
In this review written together with the Moleuclar Neuropharmacology group at the Dept. of Neuroscience and Pharmacology we provide an overview of the SLC6 neurotransmitter transporters with focus on the recent progress in understanding the structure, function and pharmacology of these neuropharmacologically important transporters.
Group Members
Professor
Kristian Strømgaard
Associate professor
Anders S. Kristensen
Postdocs
Jacob Andersen
Anders Bach
Nicolai Stuhr-Hansen
Lena Sørensen
PhD students
Louise Albertsen (Novo Nordisk)
Jonas N. N. Eildal
Christel B. Jensen
Klaus B. Nissen
Niels G. Nørager
Søren W. Pedersen
Mette H. Poulsen
Pella Söderhielm
Theis S. Wilbek
Laboratory technologist
Shahrokh Padrah
MSc students
Julie Jung Andersen (Novo Nordisk)
Anne Callesen (IMB)
Rune Christensen
Sinan Kilic (Princeton U.)
Helle Bakke Krog
Mark Bonefeld Nielsen (U. Texas)
Kristoffer Ringsted
Anders Ruskov-Nielsen (IMB)
Student worker
Tobias Rønsbjerg
Former Group Members
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