Claus Selch Larsen

Scientific Career

Professor, Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, 1998.
Director, Pharmaceutical Research, H. Lundbeck A/S, 1991.
Manager, Basic Research, Foss Electric, 1990.
DSc, Department of Pharmaceutics, Royal Danish School of Pharmacy, 1990.
Associate Professor,Department of Pharmaceutics, Royal Danish School of Pharmacy, 1979.
PhD, Department of Pharmaceutics, Royal Danish School of Pharmacy, 1978.
MSc (pharmacy), Department of Pharmaceutics, Royal Danish School of Pharmacy, 1975.

Research Interests

Design of innovative parenteral depot formulations with focus on intra-articular injection.
In vitro release methods for investigation of drug release from controlled release parenterals.
Prodrug design and salt formation.
Pharmaceutical Preformulation. Physical chemical characterization and stability assessment of drug substances.

Teaching

(Danish only)
Pharmaceutical Preformulation
Chemical Reactivity and Stability of Drugs
Bachelor’s Project in Pharmacy
Drug Design and Discovery
Drug Formulation
Advanced drug delivery

Supervision

Theses in Danish
Theses in English

Publications

Publications 2007 - present
Click on the headline to see list

2002-2006
Larsen, S.W; Østergaard, J; Friberg-Johansen, H; Jessen, M.N.B; Larsen, C.
In vitro assessment of drug release rates from oil depot formulations intended for intra-articular administration.
Eur. J. Pharm. Sci. 29, 348-345. 2006.
Nielsen A.B; Frydenvang, K; Liljefors, T; Buur, A; Larsen C
Assessment of the combined approach of N-alkylation and salt formation to enhance aqueous solubility of tertiary amines using bupivacaine as a model drug.
Eur J Pharm Sci 24, 85-93. 2005.
Nielsen A.B; Buur, A; Larsen C.
Bioreversible quaternary N-acyloxymethyl derivatives of the tertiary amines bupivacaine and lidocaine – synthesis, aqueous solubility and stability in buffer, human plasma and simulated intestinal fluid.
Eur J Pharm Sci, 24, 433-440. 2005.
Petersen, B.T; Østergaard, J; Larsen, S.W; Larsen, C.
Characterization of the rotating dialysis cell as an in vitro model simulating the pharmacokinetic fate of drugs administered intra-articularly in the form of various depot formulations.
Eur J Pharm Sci, 25, 73-79. 2005.
Nielsen, A.B; Buur, A; Larsen, C.
Bioreversible quaternary N-acyloxymethyl derivatives of the poorly soluble tertiary amine Lu 28-179 – synthesis, pharmaceutical chemical characterization and bioavailability studies in the dog.
Eur J Pharm 26, 421-428. 2005.       
Petersson, K; Larsen, C.
Alginate-based in situ gelling suspensions comprising N(4)-alkyloxycarbonyl derivatives of cytosine: zero-order release and effect of physicochemical properties.
Drug Devel Ind Pharm 31, 667-675. 2005.
Østergaard, J; Larsen, S.W; Parshad, H; Larsen, C.
Bupivacaine salts of diflunisal and other aromatic hydroxycarboxylic acids: aqueous solubility and release characteristics from solutions and suspensions using a rotating dialysis cell.
Eur J Pharm Sc 26, 280-287. 2005.
Parshad, H; Frydenvang, K; Liljefors, T; Sørensen, H.O; Larsen, C.
Aqueous solubility study of salts of benzylamine derivatives and p-substituted benzoic acid derivatives using X-ray crystallographic analysis and solution calorimetry.
Int J Pharm 269, 157-168. 2004.
Larsen, S.W; Ankersen, M; Larsen, C.
Kinetics of degradation and oil solubility of ester prodrugs of a model dipeptide (Gly-Phe).
Eur. J. Pharm. Sci 22, 399-400. 2004.
Østergaard, J; Khanbolouki, A; Jensen, H; Larsen, C.
Complexation between low molecular weight cationic ligands and negatively charged polymer as studied by capillary electrophoresis frontal analysis.
Electrophoresis 25, 3168-3175. 2004.
Petersson, K; Pedersen, B.T; Stærk, D; Krogsfelt, A.K; Larsen, C.
N⁶-alkyloxycarbonyl derivatives of cytosine. Physicochemical characterization, and cytosine regeneration rates and release from alginic acid gels.
Eur J Pharm Sci 23, 337-345. 2004.
Østergaard, J; Schou, C; Larsen, C; Heegaard, N.H.H.
Effect of Dextran as a Run Buffer Additive in Drug-Protein Binding Studies Using Capillary Electrophoresis Frontal Analysis.
Anal Chem 75, 207-214. 2003.
Østergaard, J; Hansen, S.H; Larsen, C; Schou, C; Heegaard, N.H.H.
Determination of octanol-water partition coefficients for carbonate esters and other small organic molecules by microemulsionelectrokinetic chromatography. Electrophoresis 24, 1038-1046. 2003.
Larsen, S.W; Sidenius, M; Ankersen, M; Larsen, C.
Kinetics of degradation of 4-imidazolidinone prodrug types obtained from reacting prilocaine with formaldehyde and acetaldehyde.
Eur J Pharm Sci 20, 233-240. 2003.
Parshad, H; Frydenvang, K; Liljefors, T; Cornett, C; Larsen, C.
Assessment of drug salt release from solutions, suspensions and in situ suspensions using a rotating dialysis cell.
Eur J Pharm Sci 19, 263-272. 2003.
Larsen, C; Larsen, S.W; Østergaard, J; Pedersen, B.T.
Dansk patentansøgning (PA 2003 01748) Drug-containing vehicles for local administration of active drug substances. 2003.
Larsen, D.B; Parshad, H; Fredholt, K; Larsen, C.
Characteristics of drug substances in oily solutions. Drug release rate, partitioning and solubility.
Int J Pharm 232,107-117. 2002.
Parshad, H; Frydenvang, K; Liljefors, T; Larsen, C
Correlation of aqueous solubility of salts of benzylamine with experimentally and theoretically derived parameters. A multivariate data analysis approach.
Int J Pharm 237, 193-207. 2002.
Larsen, D.B; Joergensen, S; Olsen, N.V; Hansen, S.H; Larsen, C.
In vivo release of bupivacaine from subcuteneously administered oily solution. Comparison with in vitro release.
J Control Rel 81, 145-154. 2002.
Østergaard, J; Schou, C; Larsen, C; Heegaard, N.H.H.
Evaluation of capillary electrophoresis-frontal analysis for the study of low molecular weight drug-human serum albumin interactions.
Electrophoresis 23, 2842-2853. 2002.
Larsen, C; Østergaard, J
Design and Applications of prodrugs.
In Textbook of drug design and discovery (Eds.: P. Krogsgaard-Larsen, T. Liljefors and U. Madsen), Tayor & Francis, London, pp 411-458. 2002.
Larsen C
Dansk patentansøgning (PA 2002 00798) Pharmacologically active salts. 2002.