DRA PhDs

2011

Jensen, Malene Hillerup obtained the PhD degree on November 24, 2011 based on the thesis: Structural and Biophysical Characterisation of Self-Association Mechanisms of Two Long-Acting Insulin Analogues
Main supervisor: Marco van de Weert, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Novo Nordisk A/S

Fanø, Mathias obtained the PhD degree on November 17, 2011 based on the thesis: Protein comparability using in vitro methods
Main supervisor: Sven Frøkjær, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Danish Medicines Agency

Pinholt, Charlotte obtained the PhD degree on October 19, 2011 based on the thesis: Influence of side-chain modifications on the adsorption behaviour of proteins to hydrophobic surfaces
Main supervisor: Sven Frøkjær, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Novo Nordisk A/S

Franzen, Ulrik obtained the PhD degree on October 14, 2011 based on the thesis: Pharmaceutical characterization of liposomes by capillary electropheresis
Main supervisor: Jesper Østergaard, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Statens Serum Institut

Agnolet, Sara obtained the PhD degree on July 11, 2011 based on the thesis: 1H-NMR and HPLC-based metabolomics combined with hyphenated HPLC-SPE-NMR methods for the investigation of herbal remedies and medicinal plants
Main supervisor: Dan Stærk, LIFE (previously Department of Medicinal Chemistry, The Faculty Of Pharmaceutical Sciences)
International PhD student, Leiden University, Netherlands/PHARMA

Erichsen, Mette Norman obtained the PhD degree on June 28, 2011 based on the thesis: Design and synthesis of subtype selective ligands for the human escitatory amino acid transporters (EAATs) and design and synthesis of novel selective phospodiesterase 10A (PDE10A) inhibitors
Main supervisor: Povl Krogsgaard-Larsen, Department of Medicinal Chemistry
Industrial partner: H. Lundbeck A/S 

Wang, Xiaole obtained the PhD degree on May 17, 2011 based on the thesis: Functional and structural studies of neuronal D-serine transporter Asc1
Main supervisor: Jette Sandholm Kastrup, Department of Medicinal Chemistry
Industrial partner: H. Lundbeck A/S

Frost, Anna Buus obtained the PhD degree on March 18, 2011, based on the thesis: Characteristics of Drug Delivery Systems for Intra-Articular Administration and the Potential for Establishing In Vitro In Vivo Correclations for These
Main supervisor: Claus Selch Larsen, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Novo Nordisk A/S

Henrik Tønsberg obtained the PhD degree on February 11, 2011, based on the thesis: Effects of bile on the oral absorption of poorl water-soluble drugs in rats
Main supervisor: Anette Müllertz, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: H. Lundbeck A/S

Charlotte Rode Mosbæk obtained the PhD degree on February 2, 2011, based on the thesis: Small angle X-ray scattering studies of blood coagulation factor VII and antibodies at high concentration
Main supervisor: Bente Vestergaard, Department of Medicinal Chemistry
Industrial partner: Novo Nordisk A/S

Nordly, Pernille obtained the PhD degree on January 20, 2011, based on the thesis: Formulation of Vaccine Adjuvants - Modulating the Adjuvant Activity of DDA/TDB Liposomes with Immunopotentiators
Main supervisor: Hanne Mørck Nielsen, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Statens Serum Institut

Koradia, Vishal obtained the PhD degree on January 18, 2011, based on the thesis: Understanding implications of anhydrate-hydrate forms in pharmaceutical development
Main supervisor: Jukka Rantanen, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: H. Lundbeck A/S

2010

Bornholdt, Jan obtained the PhD degree on November 25, 2010, based on the thesis: Ring-opening of novel N-sulfonyl activated aziridines with organocopper reagents
Main supervisor: Jesper Langgaard kristensen, Department of Medicinal Chemistry
Industrial partner: LEO Pharma A/S

Madsen, Henriette Baun,obtained the PhD degree on November 2, 2010, based on the thesis: Penetration and interaction of ISCOM nanoparticles with the skin
Main supervisor: Hanne Mørck Nielsen, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Coloplast A/S

Maltesen, Morten Jonas, obtained the PhD degree on July 21, 2010, based on the thesis: Powder properties and structural aspects of solid state insulin formulations
Main supervisor: Marco van de Weert, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Novo Nordisk A/S

Vasanthanathan, Poongavanam obtained the PhD degree on July 10, 2010, based on the thesis: Cytochrome P450 in action: Rationalization and prediction through in silico modeling of CYP1A2
Main supervisor: Flemming Steen Jørgensen, Department of Medicinal Chemistry
International PhD student, Leiden University, Netherlands

Ilsøe-Kristensen, Søren obtained the PhD degree on June 9, 2010, based on the thesis: Drug prescribing at the interface between hospitals and primary care in a cohort of heart failure patients
Main supervisor: Mette Rasmussen, Department of Pharmacology and Pharmacotherapy
Industrial partner: Danish Medicines Agency

Johansen, Lars Dan obtained the PhD degree on June 18, 2010, based on the thesis: Functional characterization of the G protein-coupled receptor GPRC6A
Main supervisor: Hans Braüner-Osborne, Department of Medicinal Chemistry
Industrial partner: LEO Pharma A/S

Rasmussen, Tue obtained June 15, 2010 the PhD degree based on the thesis: The molecular chaperone alpha-crystallin as an excipient for protein formulations. 
Main supervisor: Marco van de Weert, Department of Pharmaceutics and Analytical Chemistry
International PhD student, Leiden University, Netherlands/PHARMA

Nielsen, Trine Damgaard obtained April 12, 2010 the PhD degree based on the thesis: Investigation of the Mnemonic Deficits in the Sub-Chronic PCP Model of Schizophrenia 
Main supervisor: Suzanne L. Hansen, Department of Pharmacology and Pharmacotherapy
Industrial partner: H. Lundbeck A/S

Larsen, Jesper Tungelund obtained April 8, 2010 the PhD degree based on the project: Impurities in Drugs - Analysis of Drug-Excipient Reactions.
Main supervisor: Steen Honoré Hansen, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Anders Bach Nielsen, GEA/Hexal

Nielsen, Anne Flachs obtained March 8, 2010 the PhD degree based on the project: Microencapsulation by Spray Coating in Wurster Fluid Bed - Effects of Atomisation related variables.
Main supervisor: Jukka Rantanen, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Lars Hovgaard, Novo Nordisk A/S and Poul Bertelsen, Nycomed A/S

Krogsgaard-Larsen, Niels obtained February 1, 2010 the PhD degree based on the thesis: Carbene Mediated C-H Insertion into Phenyl Piperazine and Analogous Structures - An Approach to Synthesise Polycyclic, Neuroactive Scaffolds
Main supervisor: Mikael Begtrup, Department of Medicinal Chemistry
Industrial partner: Jan Kehler, H. Lundbeck A/S

Thybo, Pia obtained January 28, 2010 the PhD degree based on the thesis: Formulation and stabilization of the Amorphous State of Poorly Soluble Drug Compounds Manufactures by Spray Drying Process
Main supervisor: Jukka Rantanen, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Hexal A/S

Jacobsen, Ramune obtained January 10, 2010 the PhD degree based on the project:
Patient-Related Barriers to Cancer Pain Management with Opioid Analgesics and Healthcare Professionals' Rationale to Choose Fentanyl for Cancer Pain Patients.
Main supervisor: Claus Møldrup, Department of Pharmacology and Pharmacotherapy
Industrial partner: Lars Popper, Nycomed Danmark ApS  and Per Sjøgren, Multidisciplinary Pain Centre, Rigshospitalet

Bergmann, Rikke obtained December 1, 2009 the PhD degree based on the thesis: Computational studies of p38 MAP Kinase, Molecular Dynamics and GRID-Based Scaffold Hopping
Main supervisor: Flemming Steen Jørgensen, Department of Medicinal Chemistry
Industrial partner: Morten Dahl Sørensen, LEO Pharma A/S

Kaae, Birgitte Høiriis obtained November 30, 2009 the PhD degree based on the thesis: Design and Synthesis of Dimeric Ligands - Optimization of selectivity and potency of glutamate receptor ligands
Main supervisor: Ulf Madsen, Department of Medicinal Chemistry
Industrial partner: Per Sauerberg, Novo Nordisk A/S

Hansen, Martin obtained August 27, 2009 the PhD degree based on the thesis: Anticoccidials in the environment: Occurence, fate, effects and risk assessment of ionophores
Main supervisor: Bent Halling-Sørensen, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Asbjørn Brandt, Danish Medicines Agency

Nielsen, Simon Dalsgaard obtained July 8, 2009 the PhD degree based on the thesis: Development of an N-O Linker for fluorous phase chemistry and fluorous parallel synthesis of a piperazinedione fused tricyclic library
Main supervisor: Mikael Begtrup, Department of Medicinal Chemistry
Industrial partner: H. Lundbeck A/S

Sejberg, Jimmy Jens Povlsen obtained July 9, 2009 the PhD degree based on the thesis: Synthesis of Bicyclic Acidic Amino Acids as Conformationally Restricted Mimetics of Glu or Asp & Work Towards the Enantioselective Total Synthesis of Cardinalin 3
Main supervisor: Mikael Begtrup, Department of Medicinal Chemistry
Industrial partner: Novo Nordisk A/S

Deryabina, Maria A. obtained May 25, 2009 the PhD degree based on the thesis: Electrochemical techniques for studies on drug compounds: Physicochemical characterisation and quantitative analysis
Main supervisor: Henrik Jensen, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Kim Sonne, LEO Pharma A/S

Sickmann, Helle obtained May 18, 2009 the PhD degree based on the thesis:
Glycomatergic neurotransmission under physiological and diabetic conditions - involvement of brain glycogen
Main supervisor: Arne Schousboe, Department of Pharmacology and Pharmacotherapy
Industrial partner: Stephan Daniël Bouman, Novo Nordisk A/S

Ravn, Carsten obtained May 7, 2009 the PhD degree based on the thesis:
Near-infrared chemical imaging in formulaation development of solid dosage forms
Main supervisor: Claus Cornett, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Erik Skibsted, Novo Nordisk A/S

Andersen, Jacob obtained April 14, 2009 the PhD degree based on the thesis: Interactions of antidepressants with serotonin and norepinephrine transporters - mutational analysis and Structure-Activity Relation studies
Main supervisor: Kristian Strømgaard, Department of Medicinal Chemistry
Industrial partner: Benny Bang-Andersen and Jan Egebjerg, H. Lundbeck A/S

Lind, Marianne obtained March 16, 2009 the PhD degree based on the thesis: Mechanisms for Oral Absorption of Poorlly Water-Soluble Compounds
Main supervisor: Anette Müllertz, Department of Pharmaceutics and Analytical Chemistry.
Industrial supervisor: René Holm, H. Lundbeck A/S

Bach, Anders obtained February 13, 2009 the PhD degree based on the thesis: Targeting protein-protein interactions: Inhibitors of cMyc/Max and PDZ domain proteins 
Main supervisor: Kristian Strømgaard, Department of Medicinal Chemistry. 
Industrial supervisor: Ole Thastrup and Ole Hanzer, Carlsberg Biosector

Zimmermann, Anne, obtained December 8, 2008 the PhD degree based on the thesis: Enhanced Drug Dissolution Through Crystal Modification of Poorly Water-Soluble Drugs
Main supervisor: Jukka Rantanen, Department of Pharmaceutics and Analytical Chemistry
Industrial partner: Michiel Ringkjøbing Elema, H. Lundbeck A/S

Julie Rannes obtained March 14, 2008 the PhD degree based on the thesis:  Structure-function studies of proteins by site-specific incorporation of unnatural amino acids into proteins. Main supervisor: Kristian Strømgaard, Department of Medicinal Chemistry. Industrial supervisor: Leif Christensen, Novo Nordisk A/S

Sune Askjær obtained April 1, 2008 the PhD degree based on the thesis: Creating tools for ligand-based virtual screening that use the pharmacophore concept.
Main supervisor: Flemming Steen Jørgensen, Department of Medicinal Chemistry.
Industrial supervisor: Morten Langgård, H. Lundbeck A/S 

Kamilla Rolsted obtained April 24, 2008 the PhD degree based on the thesis: Evaluation of Cutaneous Cytochrome P450 Metabolism - in Relation to Topically Applied Drugs. Main supervisor: Steen Honoré Hansen, Department of Pharmaceutics and Analytical Chemistry. Industrial supervisor: Anne-Marie Kissmeyer, LEO Pharma A/S

Torben Seested Johansen obtained April 30, 2008 the PhD degree based on the thesis: Cellular clearance and metabolism of Activated Recombinant Human Coagulation Factor VII (rFVIIa) in the Liver.
Main supervisor: Hanne Mørck Nielsen, Department of Pharmaceutics and Analytical Chemistry
Industrial supervisor: Rupa Shree Appa, Novo Nordisk A/S

Dorthe Gybel Jensen obtained July 2, 2008 the PhD degree based on the thesis: Investigations of Pathophysiology and Pharmacology in Experimental Models of Bladder Overactivity.
Main supervisor: Majid Sheykhzade, Department of Pharmacology and Pharmacotherapy.
Industrial supervisor: Jens Peter Nørgaard, Ferring

Dennis Christensen obtained August 20, 2008 the PhD degree based on the thesis: Formulation Aspects of the Liposomal Adjuvant CAF01, Freeze-Drying and Quantification.
Main supervisor: Hanne Mørck Nielsen, Department of Pharmaceutics and Analytical Chemistry.
Industrial supervisor: Else Marie Agger, Statens Serum Institut

Charlotte Bacher obtained October 28, 2008 the PhD degree based on the thesis: Compressibility and compactivility of roller compacted materials.
Main supervisor: Jørn Møller-Sonnergaard, Department of Pharmaceutics and Analytical Chemistry.
Industrial supervisor: Peder Mohr Olsen, Nycomed

Luise K. Gram obtained October 29, 2008 the PhD degree based on the thesis: Impact of Carriers in the Intestinal Absorption of Organic Anions.
Main supervisor: Bente Steffansen, Department of Pharmaceutics and Analytical Chemistry
Industrial supervisor: Gerda Marie Rist, LEO Pharma A/S

Karina Thorn obtained February 19, 2007 the PhD degree based on the thesis:  Tripeptides and Tripeptidomimetic Based Prodrugs as Substrates for the Intestinal Peptide Transporter hPEPT1.
Main supervisor: Mikael Begtrup, Department of Medicinal Chemistry.
Industrial supervisor Palle Jacobsen, Novo Nordisk A/S
 

Birthe Ross obtained March 12, 2007 the PhD degree based on the thesis: Structural and functional studies on allergy and signal transduction. Main supervisor: Michael Gajhede, Department of Medicinal Chemistry.
Industrial supervisor Michael D. Spangfort, ALK-Abelló A/S
 

Tue Søeborg obtained April 3, 2007 the PhD degree based on the thesis: Endocrine disrupting compounds in semisolid topical dosage forms, Tools for human risk assessment.
Main supervisor: Bent Halling-Sørensen, Department of Pharmaceutics and Analytical Chemistry.
Industrial supervisor Marianne Skovgaard Nielsen, LEO Pharma A/S
 

Lars Harder Christensen obtained May 29, 2007 the PhD degree based on the thesis: Factors affecting basophil degranulation investigated by use of recombinant IgE antibodies specific for the house dust mite Allewrgen Der p2
Main supervisor: Erik S. Riise, Department of Pharmacology and Pharmacotherapy.
Industrial supervisor: Kaare Lund, ALK Abello A/S
 

Pernille Stigsnæs obtained June 11, 2007 the PhD degree based on the thesis: Pharmaceutical  Aspects of PEGylated Glucogon.
Main supervisor: Sven Frøkjær, Department of Pharmaceutics and Analytical Chemistry.
Industrial supervisor: Simon Bjerregaard Jensen, Novo Nordisk A/S
 

Minna Grønning Madsen obtained June 14, 2007 the PhD degree based on the thesis: Studies on insulin amyloid fibrillation; formation, structure, and detection. Main supervisor: Sven Frøkjær, Department of Pharmaceutics and Analytical Chemistry. Industrial supervisor: James Flink, Novo Nordisk A/S

Marie Otto obtained July 3, 2007 the PhD degree based on the thesis: Investigation of the role of drug metabolism in idiosyncratic drug toxicity. Main supervisor: Steen Honoré Hansen, Department of Pharmaceutics and Analytical Chemistry. Industrial supervisor: Lars Dalgaard, H. Lundbeck A/S

Arne Hagsten obtained November 7, 2007 the PhD degree based on the thesis: Identifying sources of batch to batch variation in processability 
Main supervisor: Lars Hovgaard, Department of Pharmaceutics and Analytical Chemistry.
Industrial supervisor: Crilles Casper Larsen, Ferring International

Petrine Wellendorph Frederiksen obtained January 19, 2006 the PhD degree based on the thesis: Cloning and characterization of GPRC6A: A novel G-protein coupled receptor.
Main supervisor: Hans Bräuner-Osborne, Department of Medicinal Chemistry.
Industrial supervisor Jan Egebjerg, H. Lundbeck A/S 

Kasper Bø Hansen obtained March 28, 2006 the PhD degree based on the thesis: Studies on the Molecular Pharmacology of Recombinant NMDA Receptors. Main supervisor: Hans Bräuner-Osborne, Department of Medicinal Chemistry.
Industrial supervisor Jan Egebjerg, H. Lundbeck A/S   
 

Morten Lysén obtained May 19, 2006 the PhD degree based on the thesis: Synthesis and Application of Aryl and Heteroarylboronic Acid Derivatives.
Main supervisor: Mikael Begtrup, Department of Medicinal Chemistry.
Industrial supervisor Fredrik Bjørkling, LEO Pharma A/S
 

Rikke Andersen obtained June 9, 2006 the PhD degree based on the thesis: Drug Delivery of Tripeptidomimetics via hPEPT1: In Silico and in Vitro Investigations of Structure-Affinity Relationships.
Main supervisor: Bente Steffansen,  Department of Pharmaceutics and Analytical Chemistry.
Industrial supervisor Eva Steiness, Zealand Pharmaceuticals A/S  
 

Charlotte Grube Jørgensen obtained July 3, 2006 the PhD degree based on the thesis: Synthesis of Glutamate and GABA Receptor Ligands: Ibotenic Acid and Muscimol Analogues containing 3-Isothiazolols or 1-Pyrazolols.
Main supervisor: Ulf Madsen, Department of Medicinal Chemistry.
Industrial supervisor Jan Kehler, H. Lundbeck A/S 
 

Peter Naur obtained August 8, 2006 the PhD degree based on the thesis: Structural Studies of Ionotropic Glutamate Receptors. Interactions with Ligands.
Main supervisor: Jette Sandholm Kastrup, Department of Medicinal Chemistry
Industrial supervisor Jan Egebjerg, H. L. Lundbeck A/S

Florent Revel, obtained August 17, 2006 the PhD degree based on the thesis: In search for seasonal genes: Implication of the KiSS-1/GPR54 system in the seasonal control of reproduction
Main supervisor: Povl Krogsgaard-Larsen, Department of Medicinal Chemistry
Industrial supervisor: Jens D. Mikkelsen, Azign Bioscience (now NeuroSearch)


Kasper Harpsøe obtained August 23, 2006 the PhD degree based on the thesis: Computational Studies on the Allosteric Modulations of AMPA receptors. Main supervisor: Tommy Liljefors, Department of Medicinal Chemistry.
Industrial supervisor Dan Peters, NeuroSearch A/S
 

Anders Søhoel obtained November 8, 2006 the PhD degree based on the thesis: Absorption Rates of Insulin Analogues Can Be Affected Iodination.
Main supervisor: Sven Frøkjær, Department of Pharmaceutics and Analytical Chemistry. Industrial supervisor Peter Thygesen, Novo Nordisk A/S
 

Kasper Huus obtained November 15, 2006 the PhD degree based on the thesis: Insulin-Ligand Interactions: Thermal and Chemical Stability Aspects.
Main supervisor: Sven Frøkjær, Department of Pharmaceutics and Analytical Chemistry. Industrial supervisor Helle Birk Olsen, Novo Nordisk A/S

Susanne Hostrup Møllmann* obtained December 21, 2005 the PhD degree based on the thesis: Studies on the Adsorption of Human Insulin to Hydrophobic Surfaces.
Main supervisor: Sven Frøkjær, Department of Pharmaceutics and Analytical Chemistry.
Industrial supervisor Jens T. Bukrinsky, Novo Nordisk A/S

* not funded by DRA, but as a PhD-student enrolled in DRA.