Drug Transporters in ADME

Research in the group
We investigate how the absorption, distribution, metabolism and excretion of drugs are influenced by membrane transporters. This includes studies on intestinal absorption of drugs and prodrugs, via nutrient transporters, transport of compounds though blood-brain barrier models, and studies of drug excretion in the kidneys. The practical work includes physicochemical studies of drugs, prodrugs and model drugs, ADME studies in cell models and characterisation of relevant membrane transport proteins.
The group consists of 3 associate professors, one assistant professor, two post doc's and  a technician. We work in a cross-disciplinary fashion and can offer an exciting work environment.
 

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Supervisors
You can read more about the supervisors  through the following page and find the supervisors in question

You can find the supervisors in building13 - Nordblokken

Specialevejledere
Alle vejledere sidder i bygning 13 - Nordblokken

Birger Brodin
Lektor
E-mail: bbr(at)farma.ku.dk
Telefon: 35 33 61 69
Rum: 424a
My main area of interest is drug transporters in barrier tissues. Previous research have focused on peptide transporters in barrier tissues such as intestinal epithelium, kidney and lung. Methods include radioisotope flux studies, immunohistochemistry using confocal laser scanning microscopy, molecular biology and electrophysiology. Projects are performed in close collaboration with colleauges at the department, as well as external academic and industrial partners. At the moment I focus on characterisation of cell models of theblood-brain barrier. Transporter expression, receptor-mediated uptake of drug compounds and regulation of barrier properties.

• Characterisation of cell models of the blood-brain barrier. Transporter expression, receptor-mediated uptake of drug compounds and regulation of barrier properties

Specialer

Bente Steffansen
Lektor
E-mail: bds(at)farma.ku.dk
Telefon: 35 33 62 21
Rum: 421
In vitro characterization of molecular drug delivery and drug-drug/drug excipent interactions on membrane transporters.

 Specialer

Carsten Uhd Nielsen
Lektor
E-mail: cun(at)farma.ku.dk
Telefon: 35 33 64 72
Rum: 423a
Specialer

Mie Larsen
Adjunkt
E-mail: mla(at)farma.ku.dk
Telefon 35 33 65 44
Rum: 13-419
Specialer
How can a formulation design with focus on membrane transporters alter drug pharmacokineitcs and -dynamics (PK/PD)? By methods such as radioisotope transport studies in cell models or whole tissue preparations, molecular biology and analytical chemistry this is investigated in vitro and in vivo.
Specialer

Tidligere specialer udført i gruppen
Affinitet og translokation via HPEPT1 i forhold til udvalgte substraters ladning (2007)
Karakterisering af basolateral optag af dipeptidet glycyl-sarosin i intestinal cellemodellen CACO-2 (2006)
In vitro studie af liposomer til topikal administration (2006)
Functional analysis of genetic variants of the human proton-coupled peptide transporter hPEPT1 (2005)
ACE-inhibitors affinity for- and transport via intestinal di/tripeptide transporter PEPT1 (2005)

Muligheder for eksterne specialer
DTA-gruppen har løbende eksterne specialestuderende i såvel ind-  som udland, kontakt vejlederne for muligheder.