Specialer

Frants Roager Lauritsen
Professor
E-mail: frl(at)farma.ku.dk
Telefon: 35 33 62 68
Rum 13 – 633 b

 Transformation of drugs and health care products into toxic compounds during chlorination of drinking and swimming pool water.
Recent research has shown that toxic disinfection by-products are produced, when drinking and swimming pool water is disinfected by chlorination. For example, common iodinated X-ray contrast media produce highly genotoxic and cytotoxic iodinated by-products and many health care products produce chloramines that induce asthma in children. It is the purpose of this project to study the production of such toxic products directly by the help of a chemical reactor attached directly to a mass spectrometer.
Supervisor: Prof. Frants R. Lauritsen

Fast analysis of plant extracts using combined microextraction on packed syringes (MEPS) and capillary sprayer cell ESI-MS/MS
This project explores the combination of two new methods for fast analysis. In microextraction on packed syringes a complete solid phase extraction system is built into a Hamilton syringe and has the advantages of requiring very little sample (20-100 L) and reuse of the sorbent. The capillary sprayer cell is a very simple ESI-MS interface that makes it possible to analyse crude, unfiltered extracts directly. 20-40 L of the extract is simply dumped into the sprayer cell and an immediate electrospray ionization of the sample is created lasting for 10-20 minutes leaving plenty of time for MS/MS analysis. This project combines for the first time the two methods with cleaner and stronger signals as the goal.
Supervisors: Assistant professor Christian Janfelt and professor Frants R. Lauritsen.

Handheld mass spectrometry for analysis in the field
In recent years mass spectrometers so small that they are handheld and can be carried into the field for analysis have been developed. Such instruments have numerous potential applications such as on-location identification of drugs and chemicals in forensic chemistry, surveillance of places that are potentially targets for chemical terrorism and on-line monitoring and control of full-scale pharmaceutical productions. In this project we will explore the possibilities of the worlds first high performance miniature tandem mass spectrometer in combination with a novel gas sniffer.
Supervisor: Prof. Frants R. Lauritsen