Hanne Mørck Nielsen

Scientific Career

Associate Professor at the Department of Pharmaceutics and Analytical Chemistry, The Faculty of Pharmaceutical Sciences, University of Copenhagen, 2004
Assistant Research Professor at the Department of Pharmaceutics, the Royal Danish School of Pharmacy, 2002
Post doc at the Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zürich (ETH Zürich), 2001
Assistant Research Professor at the Department of Pharmaceutics,the Royal Danish School of Pharmacy, 2000
Student Instructor at the Department of Pharmaceutics, the Royal Danish School of Pharmacy, 2000
PhD, Department of Pharmaceutics, the Royal Danish School of Pharmacy, 2000
Assistant Research Professor at the Department of Pharmaceutics, the Royal Danish School of Pharmacy, 1999
Student Instructor at the Department of Pharmaceutics, the Royal Danish School of Pharmacy, 1999 

Research Interests

Interaction, uptake and processing of therapeutic biomacromolecules in cells with special focus on:
Cellular delivery of stabilized biomacromolecules in advanced formulations and 
mechanistic effects of membrane penetrating peptides on cellular drug delivery.
Studies of buccal drug delivery using the stratified TR146 cell culture model regarding enhancement and toxicity hereof incl. Characterization of the buccal TR146 cell culture model (PhD-project).

Supervision

Theses
Theses in English

Publications

Publications 2007 - present
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2006-2004
Nielsen, H.M., Aemisegger, C., Burmeister, G., Schuchter, U., Gander, B.
Effect of oil-in-water emulsions on 5-aminolevulinic acid (ALA) uptake and metabolism to PpIX in cultured MCF-7 cells. 
Pharm. Res. (2004);21: 2253-2260.
Tréhin, R., Nielsen, H.M.^, Jahnke, H.-G., Krauss, U., Beck-Sickinger, A.G.,Merkle, H.P. ^shared first authorship.
Metabolic cleavage of cell penetrating peptides in contact with epithelial models: human calcitonin (hCT) derived peptides, Tat(47-57) and penetratin(43-58). 
Biochem. J. (2004); 382; 945-956.
Tréhin, R., Krauss, U., Beck-Sickinger, A.G., Merkle, H.P., Nielsen, H.M.
Cellular uptake but low permeation of human calcitonin derived cell
penetrating peptides and Tat(47-57) through well-differentiated epithelial models. 
Pharm. Res. (2004); 21; 1248-1256.
Eirheim, H.U., Bundgaard, C., Nielsen, H.M.
Evaluation of different toxicity assays applied to proliferating cells and to stratified epithelium in relation to permeability enhancement with glycocholate.
Toxicol. In Vitro. (2004); 18; 649-657.