Curriculum vitae
Curriculum vitae
Education and degrees: 1975: cand.scient. (= M.Sc.) in Biochemistry, University of Copenhagen, 1979: lic.scient. (=Ph.D.) University of Copenhagen. 1989: dr.scient. (=D.Sc.), University of Copenhagen (UC)
Awards: Has received the ”Teaching-award 1990” from the Student Council, Danish University of Pharmaceutical Sciences (DUPS).
Has for the second time received the “Teaching-award 2003” from the Student Council, DUPS
Affiliations:
1975-1979 Ph.D.-student, Biochem.Lab. The Royal Danish School of Pharmacy, Copenhagen;
1979-1985 Post-doc.-scholarships at the same lab.;
1985-1989 associate professor, Dept.Pharmacol. Pharmacother. Danish University of Pharmaceutical Sciences (DUPS), Copenhagen;
1989-2006 “docent” (=reader) at the same department.
2006- Professor at Dept. Pharmacology & Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen
2005-2010 Adjunct professor at Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen.
Invited lecturer/chairman at more than 34 international scientific congresses/symposia in Denmark, England, France, Italy, Japan, Norway, Spain, Sweden, Switzerland, USA, Germany and The Netherlands.
Supervisor of Ph.D.-students: BS Toft (1980); S Jacobsen (1986); JR Nielsen (1988); H Linnebjerg (1988); AM Vinggaard (1992) L Mikkelsen (1993); L Lauritzen (1995), Ch Vermehren (1995); J Matz (1997) AM Strand (1997) HH Hansen (2001) G Petersen (2002) HH Svejgaard (2002) T.Johansen (2003) A.N.Madsen (2007) A.Artmann (2008) S.M.Jensen (2009) T.A.Diep (2010) N.F.Nielsen (2011) E.B.Nygaard (2012) N.W.Andersen (2013) Helle Adser (2013) Karen Kleberg Hansen (2014)
Co-supervisor of 7 PhD-students at Univ. Copenhagen and Århus University.
Post graduate Course Director: “Lipider og de store folkesygdomme – hjerte-karsygdomme og kræft” (1994, 1995)
Ph.D-Course Director: “Biological Membranes. Drug Targets and Absorption Barrier” (1995,1998, 2000, 2002, 2004, 2006, 2008, and 2010).
Teaching at Ph.D.-courses at Univ.Aarhus and at Danish Technical University
Censorship at examinations at the University of Copenhagen (1994), the Danish Technical University (1990- ), and the Department of Human Nutrition, KVL (1994 - ).
Assessment of 24 Ph.D.-theses at the UC, DUPS, The Danish Technical University, The Royal Veterinary and Agricultural University, and University of Southern Denmark and The University of Lund (Sweden).
Evaluation of research projects for the Research Council of Norway (1997,1998), for INSERM, France (2000) and for Science Foundation of Ireland (2001).
Chairman for assessment committees for 6 professorships at DUPS
Referent for the 4th edition of Nordic Nutrition Recommendations (2003)
Official opponent at D.Sc.(Pharm.) thesis (1997, 2008)
Professional advisory, or administrative committees
Member of ”International Advisory Committee” at 6 international Conferences in Italy, Switzerland, Austria, and Denmark
Member of the Supreme Governing Body of DUPS, 1989-1993,1993-1995,1999-2002
Elected Member of the Board of Directors for DUPS (2003-2007)
Member of the Board of Directors for University of Copenhagen (2007-2007)
Member of the Board of Directors at the Danish Nutrition Society (1992-2011, chairman 2008-2011)
Member of the Danish Committee on Scientific Dishonesty, (1996-1998; substitute member 1999-2002)
Member of the Board of Directors: the International Society for the Study of Fatty Acids and Lipids (ISSFAL) (1997-2001)
Member of the Danish Nutrition Council (1998-2005, vice-chairman 2003-2005)
Member of the Danish Fitness and Nutrition Council (2005-2008)
Member of ad hoc committees on ”Fat, children, and arteriosclerosis” (2001-2002), on ”Dietary prevention of obesity” (2002-2003), on “Dietary effects of Fish/fish oils on human health” (2003), on “Pregnancy and diet” (2003-2004), “Trans Fatty Acids” (2004-2006), and on “Antioxidant supplements” (2004-2006) under The Danish Nutrition Council.
Member of ad hoc committees: “Dietary supplements” and “Interventions for improving folic acid status ”Danish Veterinary and Food Administration (2003)
Member of the Permanent Food Committee, Danish Ministry of Food (2003-2005 )
Member of the board of directors for “6 om dage kampagnen (Six a day fruit/vegetables)”, a collaboration between Industry, Ministry and private organisations (2003-2005).
Chairman of the National Committee for Nutritional Research, under the Royal Danish Academy of Sciences and Letters (1998-2002, 2008-2011)
Member of the editorial board of the News Letter from the Danish Nutrition Council (2003-2005)
Member of the Proof-of-Concept Advisory Board, University of Copenhagen (2006-2007 )
Member of the Committee for Good Scientific Pracsis, University of Copenhagen (2007- ).
Chairman of the Study Board for Master of Industrial Drug Development, Faculty of Pharmaceutical Sciences, University of Copenhagen (2007-2013).
Member of the Editorial Board of Biochem.Biophys.Acta-Molecular & Cell Biology of Lipids (2008-2011)
Delegate at “EFSA First National Experts Meeting on Dietary Reference Values”, Barcelona 2009
Member of the Board of Directors for the research project “Diet, Cancer and Health”, The Danish Cancer Society (2009 - ).
Member of the Board of Directors for the Hoerslev Foundation (2010-2015)
Member of the Danish Academy of Natural Sciences (2002- )
Member of scientific societies: Danish Nutrition Society; Danish Society for Biochemistry & Molecular Biology; Danish Pharmacological Society; Danish Society for Neuroscience, American Oil Chemist`s Society; Lipidforum (Scandinavian Forum for Lipid Research and Technology); EuroFed; International Society for the Study of Fatty Acids and Lipids (ISSFAL), International Cannabinoid Research Society (ICRS).
Referee-activity on subjects of lipid research for: Prostaglandins; Biochim.Biophys.Acta; Trends Biochem.Sci..; Br.J.Nutr.; Pharmacol.Toxicol.; Agents & Actions; J.Invest.Dermatol.; Am.J.Obstet.Gynecol.; Thrombosis Res.; J.Neurochem.; Neurochem.Int.; Synapse; Placenta; Food Additives & Contaminants; J.Nutr., J.Neurosci., Cell.Mol.Life Sci., Neuroscience. Radiation Res. Br.J.Pharmacol., Obesity Rev., Chem.Phys.Lipids, Recent Patents on Endocrine Metabolism & Immune Drug Discovery, Chem.Biol.
Publishing activity: More than 130 scientific papers and one patent within ”Biochemical, nutritional and pharmacological roles of lipids”
Member of Organising Committees for International Congresses
1st Int. Symposium on Trans Fatty Acids, Rungsted, Denmark, Sept. 2005
9th Nordic Nutrition Conference, Copenhagen, Denmark, June 2-4, 2008
20th Annual International Cannabinoid Research Symposium, ICRS, Lund, Sweden, July 23-27, 2010
Grants: Has received major research grants from Margarine Research Foundation (MIFU), Danish Medical Research Council, NovoNordisk Foundation, Lundbeck Foundation, Carlsberg Foundation. Julie Damms Memorial Foundation. Augustinus Foundation. Ferrosan. Proof-of-Concept Committee at University of Copenhagen, IMK-Almene Fond, UNIK-program.
Publications
Publications
Refereed papers
Wellner N, Tsuboi T, Madsen AN, Holst B, Diep TA, Nakao M, Tokumura A, Burns MP, Deutsch D, Ueda N, and Hansen HS, (2011) Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice., Biochim Biophys Acta Mol cel Biol Lipids, in press.
Hansen KB, Rosenkilde MM, Knop FK, Diep TA, Wellner N, Rehfeld J, Andersen UB, Holst JJ, Hansen HS (2011) 2-Oleoylglycerol signals GLP-1 release in humans. J Clin Endocrinol Metab, in press
Bennetzen MF, Andersen NW, Ahmed SS, Ahmed SM, Diep TA, Hansen HS, Richelsen B & Pedersen SB (2011) No indications of hyperactivity of the endocannabinoid system in subcutaneous adipose tissue in the obese state. Investigations in lean subjects and in obese subjects before and after weight loss. Int J Obes, in press.
Diep TA, Madsen AN, Holst B, Kristiansen MM, Wellner N, Hansen SH, Hansen HS (2011) Dietary fat decreases intestinal levels of anorectic lipids through a fat sensor. FASEB J, 25; 765-774
2000-2010
Mølhøj S, Hansen HS, Schweiger M, Zimmermann R, Johansen T, Malmløf K (2010) Effect of the cannabinoid receptor-1 antagonist rimonabant on lipolysis in rats. Eur J Pharmacol, 646; 38-45.
Pertwee R, Howlett AC, Abood ME, Alexander SPH, Di Marzo V, Elphick MR, Greasley PJ, Hansen HS, Kunos G, Mackie K, Mechoulam R, & Ross RA (2010) International Union of Pharmacology. Cannabinoid Receptors and their Ligands: Beyond CB1 and CB2. Pharm Rev, 62; 588-531.
Madsen AN, Hansen G, Paulsen SJ, Lykkegaard K, Hansen HS, Levin BE, Larsen PJ, Knudsen LB, Fosgerau K & Vrang N (2010) Long-term characterization of the diet-induced obese or diet resistant rat model: a polygenetic rat model mimicking human obesity. J Endocrinol, 206; 287-296.
Skonberg C, Artmann A, Cornett C, Hansen SH & Hansen HS (2010) Pitfalls in the use of chloroform for sample preparation and analysis of N-acylethanolamines. J Lipid Res, 51; 3062-3073.
Maccarrone M, Caspari V, Catani MV, Diep TA, Hansen HS & Avigliano L (2010) The endocannabinoid system and its relevance for nutrition. Annual Review of Nutrition 30, 423-440.
Hansen HS (2010) Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain. Exp Neurol 224; 48-55
Petersen G, Pedersen AH, Pickering D, Begtrup M & Hansen HS (2009) Effect of synthetic and natural phospholipids on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D activity. Chem Phys Lipids 162; 53-61.
Hansen HS & Diep TA (2009) N-acylethanolamines, anandamide and food intake. Biochem Pharmacol 78; 553-560.
Hansen SL, Nielsen AH, Knudsen KE, Artmann A, Petersen G, Kristiansen U & Hansen HS (2009) Ketogenic diet is antieleptogenic in pentylentetrazole kindled mice and decrease N-acylethanolamines in hippocampus. Neurochem Int 54; 199-204.
Overgaard K, Hansen HS, Hansen M, Kiens B, Kvorning T, Nielsen LN, Rasmussen LB, Aagaard PG (2009) Fysisk aktivitet, kosttilskud og sportsprodukter.(In Danish) Ugeskr læg 171; 2376-2379
Ellgren M, Artmann A, Tkalych O, Gupta A, Hansen HS, Hansen SH, Devi LA, Hurd YL (2008) Dynamic changes of endogenous cannabinoid and opiod nesocorticolimbic systems during adolescence: THC effects. Eur Neuropsychopharmacol 18; 826-834
Hansen HS & Artmann A (2008) Endocannabinoids and nutrition. J Neuroendocrinology, 20, 94-99
Artmann A, Petersen G, Hellgren LI, Boberg J, Skonberg C, Nellemann C, Hansen SH & Hansen HS (2008) Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine. Biochim Biophys Acta 1781; 200-212
Bartelt S, Timm M, Damsgaard CT, Hansen EW, Hansen HS, Lauritzen L (2008) The effect of dietary fish oil supplementation to healthy young men on oxidative burst measured by whole blood chemiluminescence. Br.J Nutr 99; 1230-1238
Degn M, Lambertsen KL, Petersen G, Meldgaard M, Artmann A, Hansen SH, Finsen B, Hansen HS & Lund TM (2007) Changes in brain levels of N-acylethanolamines and 2-arachidonoylglycerol during focal cerebral ischemia in mice. J Neurochem 103; 1907-1916.
Knudsen VK, Hansen HS, Ovesen L, Mikkelsen TB & Olsen SF (2007) Iron intake among Danish pregnant women and determinants of iron supplement use. Publ Hlth Nutr 10; 1104-1110.
Jensen SM, Johansen T, Hansen HS & Malmlöf K (2007) In vivo and in vitro microdialysis sampling of free fatty acids. J Pharmaceut Biomed Anal 43; 1751-1756
Campbell JIA, Hansen HS, Mu H & Mølgaard P (2007) Increased lipids in non-lipogenic tissues are indicators of the severity of type 2 diabetes in mice. Prostaglandins, Leukotrienes and Essential Fatty Acids, 76; 9-18
Hansen HS, Petersen G, Artmann A & Madsen AN (2006) Endocannabinoids. Eur J Lipid Sci Technol 108; 877-889.
Skibsted LH, Dragsted LO, Dyerberg J, Hansen HS, Kiens B, Ovesen L, Tjønneland A (2006) Antioxidanter og helbred (In Danish) Ugeskr Laeg 168; 2787-2789
Bojesen IN & Hansen HS (2006) Effects of unstirred water layer on membrane permeability of anandamide. J Lipid Res 47; 561-570
Knudsen VK, Hansen HS, Østerdal ML, Mikkelsen TB, Mu HL & Olsen SF (2006) Fish oil in various doses or flax oil in pregnancy and timing of spontaneous delivery: A randomized controlled trial. Br J Obstet Gynecol 536-543.
Petersen G, Sørensen C, Schmid PC, Artmann A, Tang-Christensen M, Hansen SH, Larsen, PJ, Schmid HHO & Hansen HS (2006) Precursor levels responsible for opposite levels of anandamide and oleoylethanolamide in intestine of food-deprived rats. Biochim Biophys Acta 1761; 143-150
Térova B, Petersen G, Hansen HS & Slotte JP (2005) N-acyl phosphatidylethanolamine affect the lateral distribution of cholesterol in membranes. Biochim Biohys Acta 175; 49-56
Olsen SF, Dragsted LO, Hansen HS, Michaelsen KF, Milman N, Nielsen MJ, Ovesen L., Petersen T & Tabor A. (2005) Det videnskabelige grundlag for officielle anbefalinger om kost i forbindelse med graviditet (In Danish), Ugeskr Laeger, 167; 25-31
Bojesen IN & Hansen HS (2005) Membrane transport of anandamide through resealed human red cell membranes. J Lipid Res 46; 1652-1659
Petersen G, Moesgaard B, Schmid PC, Schmid HHO, Broholm H, Kosteljanetz M & Hansen HS (2005) Endocannabinoid metabolism in human glioblastomas and meningiomas compared to human non-tumor brain tissue. J Neurochem 93; 299-309
Holt S, Rocksén D, Bucht A, Petersen G, Hansen HS, Di Marzo V, Fowler C (2004) Lipopolysaccharide-induced inflammation is not accompanied by a release of anandamide into the lavage fluid or a down-regulation of the activity of fatty acid amide hydrolase. Life Sci 76; 461-472
Ziegler HL, Hansen HS, Stærk D, Christensen SB, Kharazmi A, Hägerstrand HH & Jaroszewski J (2004) The antiparasitic compound lidochalone A is a potent echinocytogenic agent that modifies erythrocyte membrane in the concentration range where the antiplasmodial activity is observed. Antimicrob Agents Chemother 48; 4067-4071.
Nielsen MJ, Petersen G, Astrup A & Hansen HS (2004) Food intake is inhibited by an oral dose of oleoylethanolamide. J Lipid Res 45;1027-1029.
Ulbak J, Lauritzen L, Hansen HS, Michaelsen KF (2004) Diet and blood pressure in 2.5 year-old Danish children. Am J Clin Nutr 79;1095-1102.
Hansen HS & Olsen SF (2004) Sleep patterns, docosahexaenoic acid and gestational length. Am J Clin Nutr 79; 34.
Bojesen IN & Hansen HS (2003) Binding of anandamide to bovine serum albumin. J Lipid Res 44; 1790-1794
Lauritzen L & Hansen HS (2003) Which of the n-3 fatty acids should be called essential ? Lipids 38; 889-891.
Moesgaard B, Hansen HH, Hansen SL, Hansen SH, Petersen G & Hansen HS (2003) Brain levels of N-acylethanolamine phospholipids in mice during pentylenetetrazol-induced seizure. Lipids 38: 387-390.
Van der Stelt M, Hansen HH Vedhuis WB, Bär PR, Nicolay K, Veldink GA, Vliegenhart JFG & Hansen HS (2003) Involvement of the Endocannabinoid System in Acute and Slowly Neurodegenerative Diseases. Neurotoxicity Research 5; 183-200
Johansen T, Richelsen B, Hansen HS, Din N, Malmlöf K (2003) Growth hormone and diet effects on hormone sensitive lipase, lipoprotein lipase and blood lipids in old obese rats. Hormone Metab Res 35; 243-250.
Vermehren C, Hansen HS, Clausen-Beck B & Frøkjær S (2003) In vitro and in vivo aspects of N-acyl-phosphatidylethanolamine-containing liposomes. Int J Pharm 254:49-53.
Michaelsen KF, Dyerberg J, Falk E, Hansen HS, Marckmann P, Overvad K, Schack-Nielsem L, Skovby F, Sørensen K. (2002) Børn, fedt og hjerte-kar-sygdomme. (in Danish) Ugeskr Læg 164; 1334-1338 (Also published by Tidsskrift for Den norske lægeforening 122(2002)1556-1559).
Lauritzen L, Jørgensen MH, Hansen HS, Michaelsen KF (2002) Fluctuations in human milk long-chain polyunsaturated fatty acid levels in relation to dietary fish intake. Lipids 37, 237-244.
Hansen HH, Azcoitia I, Pons S, Romero J, Segura LMG, Ramos JA, Hansen HS, Fernandez-Ruiz JJ (2002) Blockade of cannabinoid CB1 receptor function protects against in vivo disseminating brain damage following NMDA-induced excitotoxicity. J Neurochem 82; 154-158.
Jensen M, Groth L, Hølmer G, Hansen HS, & Fullerton A (2002) The potential of the essential fatty acid-deficient hairless rat as a psoriasis screening model. The development and treatment of skin symptoms. Skin Pharmacol & Appl Skin Physiol 15; 401-413.
Hansen HS, Moesgaard B, Petersen G & Hansen HH (2002) Putative neuroprotectiive actions of N-acyl-ethanolamines. Pharmacology & Therapeutics, 95; 119-126
Moesgaard B, Petersen G. Mortensen SA & Hansen HS (2002) Substantial species differences in relation to formation and degradation of N-acylethanolamine phospholipids in heart tissues: an enzyme activity study. J Comp Biochem Physiol 131B; 475-482.
Hansen HH, Schmid PC, Bittigau P, Lastres-Becker I, Berrendero F, Manzanares J, Ikonomidou C, Schmid HHO, Ramos JA, Fernández-Ruiz JJ, & Hansen HS (2001) Anandamide, but not 2-arachidonoylglycerol, accumulates during in in vivo neurodegeneration. J Neurochem 78; 1415-1427
Johansen T, Hansen HS, Richelsen B & Malmlöf K (2001) The obese Göttingen minipig as a model of the metabolic syndrome: Dietary effects on obesity, insulin sensitivity and growth hormone profile. J Comp Med 51, 150-155.
Hansen HH, Ikonomidou C, Bittigau P, Hansen SH & Hansen HS (2001) Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death. J Neurochem 76; 39-46.
Lauritzen L, Hansen HS, Jørgensen MH, & Michaelsen KF (2001) The essentiality of long chain n-3 fatty acids in relation to postnatal development and function of the brain and retina. Progr Lipid Res 40; 1-94.
Petersen G, Chapman KD & Hansen HS (2000) A rapid phospholipase D assay using zirconium precipitation of anionic substrate phospholipids: application to N-acylethanolamine formation in vitro. J Lipid Res 41; 1532-1538
Hansen HS, Moesgaard B, Hansen HH & Petersen G (2000) N-Acylethanolamines and precursor phospholipids – relation to cell injury. Chem Phys Lipids 108; 135-150.
Hansen HH, Hansen SH Schousboe A & Hansen HS (2000) Determination of the phospholipid precursor of anandamide and other N-acyl-ethanolamine phospholipids before and after sodium azide-induced toxicity in cultured neocortical neurons. J Neurochem 75; 861-871.
Moesgaard B, Petersen G, Jaroszewski J, & Hansen HS (2000) Age dependent accumulation of N-acyl-ethanolamine phospholipids in ischemic rat brain: a 31P NMR and enzyme activity study. J Lipid Res 41; 985-990.
1990-1999
Petersen G & Hansen HS (1999) N-acylphosphatidylethanolamine-hydrolysing phospholipase D lacks the ability to transphosphatidylate. FEBS Lett 455; 41-44.
Hansen HH, Hansen SH, Björnsdottir I & Hansen HS (1999) Electrospray-ionization mass spectrometric method for the determination of cannabinoid precursors: N-acylethanolamine phospholipids (NAPE). J Mass Spectrometry 34; 761-767.
Moesgaard B, Jaroszewski J & Hansen HS (1999) Accumulation of N-acylethanolamine phospholipids in rat brains during post-decaptive ischemia: A 31P-NMR study. J Lipid Res 40;515-521.
Strand AM, Lauritzen L, Vinggaard AM & Hansen HS (1999) The subcellular localization of phospholipase D activities in rat Leydig cells. Mol Cell Endocrinol 152; 99-110.
Hansen HS, Moesgaard B, Hansen HH, Schousboe A & Petersen G (1999) Formation of N-acyl-phosphatidyl-ethanolamine and N-acylethanolamine (including anandamide) during glutamate-induced neurotoxicity. Lipids 34; s327-s330.
Slaaby R, Jensen T, Hansen HS, Frohman MA & Seedorf K (1998) Epidermal growth factor stimulates the activity of phospholipase D1 and D2. J Biol Chem 273; 33722-33727
Vermehren C & Hansen HS (1998) Shape changes in erythrocyte membrane induced by the absorption enhancer, didecanoylphosphatidylcholine. Int J Pharmaceutics 174; 1-8.
Hansen HS, Lauritzen L, Moesgaard B, Strand AM & Hansen HH (1998) Formation of N-acyl-phosphatidyl-ethanolamines and N-acylethanolamines - Proposed role in neurotoxicity. Biochem Pharmacol 55; 719-725.
Thoroed SM, Lauritzen L, Lambert IH, Hansen HS & Hoffmann EK (1997) Cell swelling activates phospholipase A2 in Ehrlich ascites tumour cells. J.Membrane Biology 160; 47-58
Vermehren C, Johansen P & Hansen HS (1997) Absorption and metabolism of a phospholipid absorption enhancer in rabbit nasal epithelium in vivo. Drug Metab Disposition 25; 1083-1088.
Hansen HS, Lauritzen L, Strand AM, Vinggaard AM, Frandsen Aa & Schousboe (1997) Characterization of glutamate-induced formation of N-acylphosphatidylethanolamine and N-acylethanolamine in cultured neocortical neurons. J Neurochem 69; 753-761.
Vinggaard AM, Provost JJ, Exton JH & Hansen HS (1997) mARF and RhoA regulate both the cytosolic and the membrane-bound phospholipase D from human placenta. Cell Signalling 9; 189-196.
Vermehren C, Hansen HS & Thomsen MK (1996) Time dependent effects of two absorption enhancers on the nasal absorption of growth hormone in rabbits. Int J Pharmaceutics 128; 239-250.
Vinggaard AM, Jensen T, Morgan C, Cockcroft S & Hansen HS (1996) Didecanoyl phosphatidylcholine is a superior substrate for assaying mammalian phospholipase D. Biochem J 319; 861-864.
Vinggaard AM & Hansen HS (1995) Characterization and partly purification of phospholipase D from human placenta. Biochim Biophys Acta 1258; 169-176.
Lauritzen L & Hansen HS (1995) Differential phospholipid-labelling indicates two subtypes of phospholipase D in rat Leydig cells. Biochem Biophys Res Commun 217;747-754.
Hansen HS, Lauritzen L, Strand AM, Moesgaard B & Frandsen Aa (1995) Glutamate stimulates the formation of N-acylethanolamine and N-acylphosphatidylethanolamine in cortical neurons in culture. Biochim Biophys Acta 1258; 303-308.
Thorling EB & Hansen HS (1995) Age related changes in the fatty acid composition of the fat stores in male and female Fischer rats. Biochim Biophys Acta 1258; 195-198.
Olsen SF, Hansen HS, Sandström & Jensen B (1995) Erythrocyte levels compared with reported dietary intake of marine n-3 fatty acids in pregnant women. Br J Nutr 73; 387-395.
Olsen SF, Hansen HS, Secher NJ, Jensen B & Sandström B (1995) Gestation length and birth weight in relation to intake of marine n-3 fatty acids. Br J Nutr 73; 397-404.
Hansen HS (1994) New biological and clinical roles of the (n-6)- and (n-3)-fatty acids. Nutr Rev 52; 162-167.
Lauritzen L, Nielsen LLA, Vinggaard AM & Hansen HS (1994) Agents that increase phosphatidic acid inhibits LH-stimulated testosterone synthesis in rat Leydig cells. Mol Cell Endocrinol 104;229-235.
Olsen SF, Sørensen JD, Secher NJ, Hedegaard M, Henriksen TB, Hansen HS & Grant A (1994) Fisketilskud og graviditetslængde. Ugeskr Læg 156; 1302-1307. (Same publication as the Lancet-paper, but now in Danish).
Mikkelsen L, Hansen HS, Grunnet N & Dich J (1994) Cytoprotective activity of different tocopherols in hepatocytes cultured with polyunsaturated fatty acids. Lipids 29; 369-372.
Hansen HS (1993) Possible new function of linoleic acid as a precursor for acylation of transducin, a retinal G-protein (Letter to editor). Trends Biochem.Sci. 18; 164.
Mikkelsen L, Hansen HS, Grunnet N & Dich J (1993) Inhibition of fatty acid synthesis in rat hepatocytes by exogenous polyunsaturated fatty acids is caused by lipid peroxidation. Biochim Biophys Acta. 1166; 99-104.
Lauritzen L, Hoffmann E, Hansen HS & Jensen B (1993) The effect of dietary n-3 and n-6 polyunsaturated fatty acids on volume regulation in Ehrlich ascites cells. Am J Physiol 264; C109-C117.
Abu-Zeid YA, Hansen HS, Jacobsen P, Bygbjerg IC & Dyerberg J (1993) Polyunsaturated fatty acids do not inhibit Plasmodium faciparum in vitro. Eur.J.Clin.Nutr. 47;431-436.
Vinggaard AM & Hansen HS (1993) Bradykinin and vasopressin activate phospholipase D in Leydig cells by a protein kinase C-dependent mechanism. J Endocrinol 136; 119-126.
Olsen SF, Sørensen JD, Secher NJ, Hedegaard M, Henriksen TB, Hansen HS & Grant A (1992) Randomised controlled trial of effect of fish-oil supplemntation on pregnancy duration. The Lancet 399; 1003-1007.
Vinggaard AM & Hansen HS (1991) Phorbol ester and vasopressin activate phospholipase D in Leydig cells. Mol Cell Endocrinol 79; 157-165.
Olsen SF, Hansen HS, Sommer S, Jensen B, Sørensen TIA, Secher NJ & Zachariassen P (1991) Gestational age in relation to marine n-3 fatty acids in maternal erythrocytes. A study of women in the Faroe Islands and Denmark. Am J Obstet Gynecol 164; 1203-1209.
Thomsen S, Hansen HS & Nyman U (1991) Ribosome inhibiting proteins from in vitro culture of phytolacca dodecandra. Planta Med 57; 232-236.
Hansen HS (1990) Eicosanoid levels in human skin. Letter to editor. J Invest Dermatol 93;798
Hansen HS (1990) How do (n-3)-fatty acids affect prostaglandins ? Inform 1; 644-653.
Olsen SF, Hansen HS & Jensen B (1990) Fish oil versus arachis oil food supplementation in relation to pregnancy duration in rats. Prostagland Leukotr Essent Fatty Acids 40; 255-260.
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1980-1989
Nielsen JR, Hansen HS & Jensen B (1989) Arginine vasopressin stimulates phosphoinositide turnover in an enriched rat Leydig cell preparation. Mol Cell Endocrinol 61; 181-188.
Olsen SF, Hansen HS, Jensen B & Sørensen TIA (1989) Pregnancy duration and the ratio of long-chain n-3 fatty acids to arachidonic acid in erythrocytes from Faroese women. J Intern Med. 225 suppl. 1; 185-189.
Linnebjerg H, Hansen HS & Jensen B (1989) Effect of amiloride on arachidonic acid and histamine release from rat mast cells. Agents & Actions 27; 39-42.
Hansen HS & Olsen SF (1988) Dietary (n-3)-fatty acids, prostaglandins and prolonged gestation in humans. Prog Clin Biol Res 282; 305-317.
Linnebjerg H, Hansen HS, & Jensen B (1988) Inhibition by amiloride and by Na-depletion of A23187-stimulated arachidonic acid and histamine release from rat mast cells. FEBS Lett 240; 167-170.
Hansen HS (1987) EFAs and epidermal water barrier. Letter to editor. Nutr.Rev. 45;95-96.
Olsen SF & Hansen HS (1987) Marine fat, birth weight, and gestational age: a case report. Agents & Actions 22; 373-374.
Nielsen JR, Hansen HS & Jensen B (1987) Arginine vasopressin stimulates the formation of phosphatidic acid in rat Leydig cells. FEBS Lett 288; 93-96.
Jacobsen S, Hansen HS & Jensen B (1987) Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoyl 13-acetate on the release of 14C-arachidonic acid and histamine from rat peritoneal mast cells. Biochem Pharmacol 36; 621-626
Olsen SF, Hansen HS, Sørensen TIA, Jensen B, Secher NJ, Sommer S & Knudsen LB (1986) Intake of marine fat, rich in (n-3)-polyunsaturated fatty acids may increase birth weight by prolonging gestation. The Lancet 8503; 367-369.
Hansen HS (1986) The essential nature of linoleic acid in mammals. Trends Biochem Sci 11; 263-265.
Hansen HS, Jensen B & von Wettstein-Knowles P (1986) Apparent in vivo retroconversion of dietary arachidonic to linoleic acid in essential fatty acid-deficient rats. Biochim Biophys Acta 878; 284-287
Hansen HS & Jensen B (1986) Urinary excretion of arginine-vasopressin and prostaglandin E2 after oral supplementation with unsaturated fatty acids. J Nutr 116; 198-203.
Hansen HS & Jensen B (1985) Essential function of linoleic acid when incorporated into acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate. Biochim Biophys Acta 834; 357-383.
Hansen HS, Jensen B & Warberg J (1985) Increased concentration of vasopressin in plasma of essential fatty acid-deficient rats. Nutr Res 5; 395-403.
Hansen HS & Jensen B (1985) The effect of a single oral dose of ethyl linoleate on urinary excretion of prostaglandin E2 in essential fatty acid-deficient rats. J Nutr 115; 39-44.
Hansen HS (1983) Dietary essential fatty acids and in vivo prostaglandin production in mammals. Wld Rev Nutr Diet 42; 102-134.
Hansen HS, Fjalland B & Jensen B (1983) Extremely decreased release of prostaglandin E2-like activity from chopped lung of ethyl linolenate supplemented rats. Lipids 18; 691-695.
Hansen HS & Jensen B (1983) Urinary prostaglandin E2 and vasopressin in essential fatty acid-deficient rats. Effect of linolenic acid supplementation. Lipids 18; 682-690.
Hansen HS (1982) Purification of 15-keto-prostaglandin-delta-13-reductase from bovine lung. Meth Enzymol 86; 156-162.
Hansen HS (1982) Essential fatty acid-supplemented diet increases renal excretion of immunoreactive arginine-vasopressin in essential fatty acid-deficient rats. Lipids 17; 321-322.
Hansen HS (1981) Essential fatty acid-supplemented diet increases renal excretion of prostaglandin E2 and water in essential fatty acid-deficient rats. Lipids 16; 849-854.
Toft BS & Hansen HS (1980) Glutathione-prostaglandin A1 conjugate as substrate in the purification of prostaglandin 9-keto-reductase from rabbit kidney. Prostaglandins 21; 735-746.
1974-1979
Hansen HS (1979) Purification and characterization of 15-keto-prostaglandin-delta-13-reductase from bovine lung. Biochim.Biophys.Acta 574;136-145.
Toft BS & Hansen HS (1979) Metabolism of prostaglandin E1 and glutathione conjugate of prostaglandin A1 by prostaglandin 9-keto-reductase from rabbit kidney. Biochim.Biophys.Acta 574;33-38.
Hansen HS & Bukhave K (1978) Separation of prostaglandin metabolites on Sephadex LH 20 columns. Prostaglandins 16;311-318.
Hansen HS & Toft BS (1978) 15-Hydroxyprostaglandin dehydrogenase activity in lung and kidney of essential fatty acid-deficient rats. Biochim.Biophys.Acta 529;230-236.
Bukhave & Hansen HS (1977) Elimination of low steady state concentration of 5,6-tritium-prostaglandin E2 in the pulmonary and the systemic circulations of anaesthetized rats. Biochim.Biophys.Acta 529;403-414.
Hansen HS (1976) 15-Hydroxyprostaglandin dehydrogenase – a review. Prostaglandins 12;647-679
Hansen HS (1974) Inhibition by indomethacin and aspirin of 15-hydroxyprostaglandin dehydrogenase in vitro. Prostaglandins 8;95-105.
Books, Book Chapters etc.
Dyerberg J, Hansen HS & Stender S (2010) ”Fedtstoffer”. Chapter in: ”Menneskets Ernæring” , 3nd Ed.(Astrup A, Bügel S, Dyerberg ,J. & Stender S, editors) Munksgaard Danmark, København (in Danish), in press.
Clausen RP & Hansen HS (2010) ” Opioid and cannabinoid receptors”: Chapter in ”Textbook of Drug Design and Discovery” 4th, (Krogsgaard-Larsen P, Strømgaard K & Madsen U, Eds), Taylor & Francis, 313-328.
Overgaard K, Hansen HS, Hansen M, Kiens B, Kvorning T, Nielsen LN, Rasmussen LB, Aagaard PG (2008) Fysisk aktivitet og kosttilskud – præstations og helbredsmæssige aspekter for motionister.(In Danish). Report from the Danish Nutrition and Fitness Council, 129 pages
Hansen HS (2007) Dietary poly-unsaturated fatty acids and bioactive derivatives. In Polyunsaturated Fats, Neural Function and Mental Health ( (Mouritsen OG & Crawford MA eds) Biol Skr Dan Vid Selsk 56; 61-68 (The Royal Danish Academy of Sciences and Letters) ISBN 978-87-7304-327-1.
Stender S, Dyerberg J & Hansen HS (eds) (2006) Fist International Symposium on Trans fatty acids and Health. Rungstedgaard, Rungsted Kyst, Denmark, 11-13 September 2005, Report from the Danish Fitness and Nutrition Council. Atherosclerosis supplements, vol 7, issue 2.
Skibsted L, Dragsted LO, Dyerberg J, Hansen HS, Ovesen L & Tjønneland A (2006) Antioxidanter og helbred (in Danish) . Report from the Danish Fitness and Nutrition Council, 149 pages.
Hansen HS, Petersen G & Hansen HH (2006) Neuroprotection: Glutamate and endocannabinoids. In, ”Endocannabinoids: The brain and body´s Marijuana and Beyond” (Onaivi E, Sugiura T & Di Marzo V, eds) Taylor & Francis Publishing Group, pp. 351-370.
Dyerberg J, Hansen HS & Stender S (2005) ”Fedtstoffer”. Chapter in: ”Menneskets Ernæring” , 2nd Ed.(Astrup A, Dyerberg,J. & Stender S, editors) Munksgaard Danmark, København (in Danish), ISBN 87-628-0540-1, p. 114-130.
Olsen SF, Dragsted LO, Hansen HS, Michaelsen KF, Milman N, Ovesen L, Petersen T, Tabor A (2005) Kost til gravide. Det videnskabelige grundlag for råd om kost i forbindelse med graviditet. Rapport fra Ernæringsrådet (In Danish) ISSN 0909-9859.
Richelsen B, Astrup A, Hansen GL, Hansen HS, Heitmann B, Holm L, Kjær M, Madsen SA, Michaelsen KF, Olsen SF (2003) Den danske fedmeepidemi: Oplæg til en forebyggelsesindsats(in Danish). Rapport fra Ernæringsrådet, ISBN 0909-9859.
Michaelsen KF, Dyerberg J, Falk E, Hansen HS, Marckmann P, Overvad K, Schack-Nielsen L, Skovby F & Sørensen K (2002) Børn, Fedt og Hjerte-Kar-Sygdomme. (in Danish) En rapport fra Ernæringsrådet (80 pages)
Lauritzen L, Jørgensen MH, Hansen HS, & .Michaelsen KF (2000) Dietary fish and the docosahexaenoic acid content of human milk. In: B.Koletzko, K.F.Michaelsen, & O.Hernell (eds.). Short and long term effect of breast-feeding on child health. Kluwer Academic/Plenum Publishers, New York. Adv Exp Med Biol 478: 430-434.
Hansen HS, Moesgaard B, Hansen HH & Petersen G (2000) When and where are N-acylethanolamine phospholipids and anandamide formed? Wld Rev Nutr Diet, 88; 223-227.
Petersen G & Hansen HS (1999) N-Acyl-phosphatidylethanolamine – Metabolism and possible functions. In, Proceedings of CTVO-Workshop New Applications for Vegetable Oils (also published on CTVO-net: www.fnr.de/ctvo) pp. 101-106.
Lauritzen L, Jørgensen MH, Hansen HS & Michaelsen KF (1999) Essential fatty acids and postnatal development of the brain. In, ”Brain Carrier Systems” (Paulson O, Knudsen GM, Moos T & Svejgaard T, eds.) Munksgaard, pp. 339-351.
Vermehren C, Hansen HS & Thomsen MK (1998) Medium-chain lecithin in nasal drug delivery systems: Advantages and drawbacks. In, ”Future Strategies for Drug Delivery with Particulate Systems” (Diederichs JE & Müller RH, eds.) CRC Press, Boca Raton, pp. 45-51.
Hansen HS, Vinggaard AM, Lauritzen L, Vermehren C & Strand AM (1995) A general view on mammalian phospholipases. The proceedings of the symposium ”Fish Quality – role of biological membranes” TemaNord 624; 129-140.
Vermehren C, Hansen HS & Thomsen MK (1995) Metabolism and effects of a phospholipid absorption enhancer in rabbit nasal epithelium in vitro. In, ”Phospholipids – Characterization, Metabolism and Novel Biological Applications”. (Cevc G & Paltauf F, eds.) American Oil Chemist´s Society, Campaign, USA pp. 80-100
Hansen HS (1993) Desaturation/elongation of the shorter-chain essential fatty acids and its physiological implications. In, ”Antioxidants, Free Radicals and Polyunsaturated Fatty Acids in Biology and Medicine” (Diplock AT, Gutteridge JMC, and Shukla VKS, eds.) International Food Science Centre A/S, Copenhagen, pp. 131-140.
Hansen HS (1992) Metabolism of (n-6)- and (n-3)-fatty acids. Aspects of species differences. In, Proceedings of ”The Rat as a Model for Man and Pig for Nutritional and Physiological Studies” (Jungvid H, Forshell LP & Eggum BO, eds.) Gramineer AB-AB AnalyChen-National Institute of Animal Science, DK, pp 54-66
Hansen HS (1990) Prostanoids – chemistry and analysis. In, Proceedings from ”New Horizons in the Eicosanoid Analysis of Oils, Fats, Lipids and Lipoproteins” (Shukla VKS, ed.) American Oil Chemist´s Socity
Hansen HS (1989) Linoleic acid and epidermal water barrier. In, ”Dietary w3 and w6 Fatty Acids. Biological Effects and Nutritional Essentiallity” (Galli C & Simopoulos AP, eds.) Plenum Press, New York, pp. 333-342.
Jensen B, Nielsen JR, Hansen HS & Vinggaard AM (1989) Inositol phospholipids. Hormone-stimulated metabolism in Leydig cells. In, ”Proceedings of the 15th Scandinavian Symposium on Lipids” (Shukla VKS & Hølmer G, eds.) pp. 48-52
Hansen HS (1989) Linoleic acid – Essential fatty acid and eicosanoid precursor. D.Sc.-thesis at the University of Copenhagen (86 pages) (ISBN 87-983244-0-3)
Olsen SF, Hansen HS, Sørensen TIA, Jensen B, Secher NJ, Sommer S & Knudsen LB (1987) Hypothesis: Dietary (n-3)-fatty acids prolong gestation in human beings. In, ”Prostaglandins in Clinical Research” (Schrör H & Sinzinger H, eds.) Alan R.Liss, Inc., New York, pp. 51-56
Hansen HS & Jensen B (1987) Why is linoleic acid essential? Further evidence of specificity in correction of transepidermal water loss. In, ”Polyunsaturated Fatty Acids and Eicosanoids” (Lands WEM, ed.) American Oil Chemist´s Society, Champaign, Illinois, pp. 549-554.
Hansen HS (1986) Dietary essential fatty acids and prostaglandin formation in vivo. In, ”Proceedings of the XIII International Congress on Nutrition 1985” (Taylor TG & Jenkins NK, eds.) John Libbey & Co, Ltd, London, pp.353-357.
Hansen HS (1978) Studies on prostaglandin metabolism. Ph.D.-thesis, University of Copenhagen
In popular scientific papers
Diep TA, Artmann A, Andersen NW, Hansen SH &Hansen HS (2009) Ekstra sulten af den fede mad. Lægemiddelforskning 2009, p. 16-18.
Mølhøj S, Malmlöf K, Johansen T & Hansen HS (2008) Lægemidlers effekt på fedtnedbrydning kan måles i rotter. Lægemiddelforskning 2008, p.55-57.
Hansen HS & Jørgensen K (2007) Fedtmængde og fedtkvalitet (In Danish) . Motions- og Ernæringsrådets Nyhedsbrev, 1 p. 2-3.
Madsen AN, Petersen G, Artmann A, Hansen G, Larsen PJ, Hansen HS (2006) Rottemodel for kost-induceret fedme hos mennesker (in Danish). Lægemidelforskning, p. 16-17.
Hansen HS (2005) Internationalt Symposium om transfedtsyrer (In Danish). Motions- & Ernæringsrådets Nyhedsbrev, 1; p. 7.
Degn M, Petersen G, Hansen HS & Lund TM (2005) Kroppens egne cannabinoider påvirker immunsystemet (In Danish). Lægemiddelforskning 2005; 8-9.
Petersen G, Nielsen MJ, Astrup A & Hansen HS (2005) Nyt middel mod fedme? (In Danish) Dansk Kemi, 86; 15-17.
Kristesen M, Richelsen B & Hansen HS (2004) En stor del af danskernes morgenmad består i virkeligheden af slik (in Danish). Ernæringsrådets Nyhedsbrev 2004, vol. 4, 6-7.
Hansen HS & Julin M (2004) Alt med måde – også E-vitaminer! (in Danish) Ernæringsrådets Nyhedsbrev 2004, no 4, 4-5.
Hansen HS & Richelsen B (2004) Ny diskussion om fisk og n-3 fedtsyrer (in Danish) . Ernæringsrådets Nyhedsbrev 2004, no 4, 2-3.
Petersen G, Nielsen M.J., Astrup,A. & Hansen HS (2004) Nyt middel mod fedme? (In Danish) Lægemiddelforskning, 6-7.
Hansen HS & Rosenberg LC (2004) Carnitin kan måske hjælpe svagelige ældre. (in Danish) Ernæringsrådets Nyhedsbrev 2004, no 3, 4-5.
Hansen HS & Richelsen B (2004) Antioxidanter – gavnlige, farlige eller blot uden effekt ? (ni Danish) Ernæringsrådets Nyhedsbrev, no 3, p. 1-2.
Hansen HS & Rosenberg L.C. (2004) Homocysteins betydning for hjerte-kar-sygdom er stadig uafklaret (in Danish) Ernæringsrådets Nyhedsbrev 2004 no 1, p.6-7.
Richelsen B & Hansen HS (2004) Atkins´ kostrevolution er uforenelig med sund kost (in Danish) Ernæringsrådets Nyhedsbrev 2004 no 1, p. 2-3.
Richelsen B & Hansen HS (2004) USA underkender WHO´s globale strategi vedrørende fremme af sund livsstil (in Danish) Ernæringsrådets Nyhedsbrev 2004 no 1, p.1-2.
Richelsen B & Hansen HS (2003) Tilsætning af vitaminer og mineraler samt visse andre stoffer til fødevarer (in Danish) Ernæringsrådets Nyhedsbrev 2003 no 4, p.4-5.
Hansen HS & Hansen B (2003) Animalsk fedt øger risikoen for brystkræft (in Danish). Ernæringsrådets Nyhedsbrev 2003, no 3, p.7.
Richelsen B & Hansen HS (2003) Ernæringsrådets kommentarer til ernærings- og sundhedsanprisninger (in Danish). Ernæringsrådets Nyhedsbrev 2003, n3, p. 1-2.
Jaroszewski JW, Hansen HS, Hansen SH & Schousboe A (2002) Højteknologisk metabonom-analyse (in Danish). Lægemiddelforskning. P. 6-7.
Astrup A, Stender S, Godtfredsen J & Hansen HS (2001) Kosttilskud med antioxidanter svækker virkningen af medicinsk behandling af hjerte-kar-sygdom (in Danish). Ernæringsrådets Nyhedsbrev 2001, no 4 p.2.
Hansen HS (2001) Endocannabinoider og deres fosfolipidforstadier (in Danish). Carlsbergfondets Årsskrift 2001. pp. 42-47.
Hansen HH, Hansen SH & Hansen HS (2000) Hjernens cannabis-lignende stoffer modvirker celledød (in danish) Lægemiddelforskning, p. 26-27.
Hansen HS (1998) Om videnskabelig uredelighed (In Danish). Communicatio 5; 12-13
Hansen HS, Moesgaard B, Hansen HH, Björnsdottir I, Jaroszewski JW & Hansen SH (1997) Et forsvar mod nervedød ? (in Danish). Lægemiddelforskning 1997;12-13
Vermehren C, Johansen P & Hansen HS (1997) Væksthormon gennem næsen ? (in Danish). Lægemiddelforskning 1997;22-23.
Hansen HS (1997) n-6 og n-3 fedtsyrer i menneskets ernæring (in Danish). Margasinet 3; 2-5.
Hansen HS, Lauritzen L, Vinggaard AM & Strand AM (1995) Signalprocesser styrer cellerne (in Danish). Lægemiddelforskning – en avis fra Danmarks farmaceutiske Højskole” pp. 10-11.
Hansen HS (1994) Lipidbiokemi – fra linolsyre & hudlipid over fiskeolie & graviditet til phospholipider & celleregulation. (in Danish). Dansk Kemi 75;10-13.
Hansen HS (1992) Arachidonic acid pathways as pharmacological targets (extended abstract) In, Proceedings of ”Drug Research & Pharmacological Development”, Centennial of the Royal Danish School of Pharmacy. (Bundgaard H et al., eds.), The Royal Danish School of Pharmacy, Copenhagen, L7-L8.
Vinggaard AM & Hansen HS (1991) Ny viden om vores indre kemi (in Danish). Lægemiddelforskning – en avis fra Danmarks farmaceutiske Højskole, pp. 16-17.
Jensen B & Hansen HS (1989) Når milliarder af celler kommunikerer indbyrdes. (in Danish). Lægemiddelforskning – En avis fra Danmarks farmaceutiske Højskole, no III, pp. 6-7
Hansen HS (1989) Essentielle fedtsyrer og prostaglandiner (in Danish). Näringsforskning (stiftelsen Svensk Näringsforskning) 33;88-90
Hansen HS (1986) Prostaglandiner og graviditetslængde. (in Danish). In, ”Lægemiddelforskning – En avis fra Danmarks farmaceutiske Højskole”, pp. 10-11
Hansen HS (1984) Prostaglandiner. (in Danish). Arch.Pharm.Chem. 91;655-661
Patents
Hansen HS, Diep TA, Andersen NW, Holst JJ & Rosenkilde MM (2009/2010) Treatment of insulin resistance and obesity by stimulating GLP-1 release. PCT/DK2010/050161
Hansen HS, Petersen G, Artmann A & Larsen PJ (2005/2007) Inhibitors of anorexic lipid hydrolysis for the treatment of eating disorders. WO 2007/006319
Hansen HS, Astrup A, Nielsen MJ & Petersen G (2002) Patent application nr. PA 2002 01566 (withdrawn)
