Helle Hald

Postdoc

Peer reviewed:

Venskutonyté, R., Frydenvang, K., Hald, H., de Rabassa, A. C., Gajhede, M., Ahring, P. K. and Kastrup, J. S. (2012) Kainate induces various domain closures in AMPA and kainate receptors. Neurochem. Int. In press.

Jensen, J. M., Ernst, H. A., Wang, X., Hald, H., Ditta, A. C., Ismat, F., Rahman, M. and Mirza, O. (2012) Functional Investigation of Conserved Membrane-Embedded Glutamate Residues in the Proton-Coupled Peptide Transporter YjdL. Protein Pept. Lett. 19: 282-287.

Frydenvang, K., Pickering, D. S. Greenwood, J. R., Krogsgaard-Larsen, N.,Brehm, L, Nielsen, B., Vogensen, S. B., Hald, H., Kastrup, J. S., Krogsgaard-Larsen, N., Clausen, R. P. (2010) Biostructural and Pharmacological Studies of Bicyclic Analogues of the 3-Isoxaxolol Glutamate Receptor Agonist Ibotenic Acid. J. Med. Chem. 53: 8354-8361.

Wang, X., Hald, H., Ernst, H. A., Egebjerg, J., Christensen, K. V., Gajhede, M., Kastrup, J. S. and Mirza, O. (2010) Over-expression, Purification and Characterization of an Asc-1 Homologue from Gloeobacter violaceus. Protein Expr. Purif. 71: 179-183.

Ernst, H. A., Pham, A., Hald, H., Kastrup, J. S., Rahman, M. and Mirza, O. (2009) Ligand Binding Analyses of the Putative Peptide Transporter YjdL from E. coli Display a Significant Selectivity Towards Dipeptides. Biochem. Biophys. Res. Commun. 389: 112-116.

Hald, H., Ahring, P. K., Timmermann, D. B., Liljefors, T., Gajhede, M. and Kastrup, J. S. (2009) Distinct Structural Features of Cyclothiazide are Responsible for Effects on Peak Current Amplitude and Desensitization Kinetics at iGluR2. J. Mol. Biol. 391: 906-917.

Hald, H., Naur, P., Pickering, D. S., Sprogøe, D., Madsen, U., Timmermann, D. B., Ahring, P. K., Liljefors, T., Schousboe, A., Egebjerg, J., Gajhede, M. and Kastrup, J. S. (2007) Partial Agonism and Antagonism of the Ionotropic Glutamate Receptor iGluR5. Structures of the Ligand-Binding Core in Complex with Domoic Acid and 2-amino-3-(5-tert-butyl-2-(phosphonomethoxy)-4-isoxazolyl)propionic acid. J. Biol. Chem. 282: 25726-25736.

Other:

Hald, H. and Mirza, O. (2011) Strukturer af membranproteiner: Nøglen til rationelt lægemiddeldesign. Lægemiddelforskning. Det Farmaceutiske Fakultet, Københavns Universitet.

Hald, H. (2009) The ionotropic glutamte receptors: structural and functional studies using the methods of protein crystallography and patch clamp electrophysiology. University of Copenhagen. Faculty of Pharmaceutical Sciences. PhD thesis.