Jesper Østergaard

Scientific Career

Associate Professor, Department of Pharmaceutics and Analytical Chemistry, The Faculty of Pharmaceutical Sciences, University of Copenhagen, 2006
Assistant Professor, Department of Pharmaceutics and Analytical Chemistry, The Faculty of Pharmaceutical Sciences, University of Copenhagen, 2003
PhD., Department of Analytical and Pharmaceutical Chemistry, The Danish University of Pharmaceutical Sciences, 2003

Research Interests

Molecular interactions. Study on the non-covalent interactions of drug substances.
Development of new analytical methodologies for physical chemical characterization of drug substances.
Affinity capillary electrophoresis.
Pharmaceutical Preformulation. Physical chemical characterization of drug substances.
Design of innovative parenteral depot formulations with focus on intra-articular injection.
In vitro release methods for investigation of drug release from controlled release parenterals.
Prodrug design and salt formation.

Research projects

Molecular interaction studies

Teaching

(Danish only)
A22-1, Physical Chemistry, Lectures and class teaching
A22-2, Physical Chemistry, Laboratory Course
AF- 328, Pharmaceutical Preformulation

Supervision

Theses in Danish
Theses in English

Publications

Publications 2007 - present
Click on the headline to view list

2006 - 1999
Larsen, S. W; Østergaard, J., Friberg-Johansen, H; Jessen, M. N. B; Larsen, C. In vitro assessment of drug release rates from oil depot formulations intended for intra-articular administration.
Eur. J. Pharm. Sci. 29, 348-354. 2006.
Østergaard, J; Heegaard, N. H. H.
Bioanalytical interaction studies executed by pre-incubation affinity capillary electrophoresis.
Electrophoresis 27, 2590-2608. 2006.
Østergaard, J; Hansen, S. H; Jensen, H; Thomsen, A. E.
Pre-equilibrium capillary zone electrophoresis or frontal analysis: Advantages of plateau peak conditions in affinity capillary electrophoresis.
Electrophoresis 26, 4050-4054. 2005.
Østergaard, J; Larsen, S. W; Parshad, H; Larsen, C.
Bupivacaine salts of diflunisal and other aromatic hydroxycarboxylic acids: Aqueous solubility and release characteristics from solutions and suspensions using a rotating dialysis cell model.
Eur. J. Pharm. Sci. 26, 280-287. 2005.
Pedersen, B. T; Østergaard, J; Larsen, S. W; Larsen, C.
Characterization of the rotating dialysis cell as an in vitro model potentially useful for simulation of the pharmacokinetic fate of drugs administered intra-articularly.
Eur. J. Pharm. Sci. 25, 73-79. 2005.
Østergaard, J; Khanbolouki, A; Jensen, H; Larsen, C.
Complexation between low molecular weight cationic ligands and negatively charged polymer as studied by capillary electrophoresis frontal analysis.
Electrophoresis 25, 3168-3175. 2004.
Østergaard, J; Heegaard, N. H. H. 
Capillary electrophoresis frontal analysis: Principles and applications for the study of drug-plasma protein binding.
Electrophoresis 24, 2903-2913. 2003.
Østergaard, J.
Aspects of reversible drug-human serum albumin binding. 
Ph.D. Thesis. The Danish University of Pharmaceutical Sciences. ISBN 87-7834-552-9, 2003
Østergaard, J; Hansen, S. H; Larsen, C; Schou, C; Heegaard, N. H. H.
Determination of octanol-water partition coefficients for carbonate esters and other small organic molecules by microemulsion electrokinetic chromatography. Electrophoresis 24, 1038-1046. 2003.
Østergaard, J; Schou, C; Larsen, C; Heegaard, N. H. H.
Effect of dextran as a run buffer additive in drug-protein binding studies using capillary electrophoresis frontal analysis.
Anal. Chem. 75, 207-214. 2003.
Østergaard, J; Schou, C; Larsen, C; Heegaard, N. H. H.
Evaluation of capillary electrophoresis frontal analysis for the study of low molecular weight drug-human serum albumin interactions.
Electrophoresis 23, 2842-2853. 2002.
Larsen, C. S; Østergaard, J.
Design and application of prodrugs.
In Textbook of drug design and discovery (Krogsgaard-Larsen, P., Liljefors, T., & Madsen, U., eds), pp. 410-458. Taylor & Francis, London, 2002Lepist, E.-I., Østergaard, J; Fredholt, K; Lennernäs, H; Friis, G. J.
Stability and perfusion studies of desmopressin (dDAVP) and prodrugs in the rat jejunum.
Exp. Toxic. Pathol. 51, 363-368. 1999.
Fredholt, K; Østergaard, J; Savolainen, J. & Friis, G. J.
a-Chymotrypsin-catalyzed degradation of desmopressin (dDAVP): influence of pH, concentration and various cyclodextrins.
Int. J. Pharm. 178, 223-229. 1999.