Lægemiddelteknik

Pharmaceutical Technology

The purpose of the groups’ research
Pharmaceutical Technology group is focusing on processing and material sciences around solid state and semisolid pharmaceuticals. This international group - headed by professor Jukka Rantanen - has 15 PhD students, postdocs and assistant/associate professors, and has recently established Particle Technology Laboratory (PTL) providing state-of-art lab environment for process research covering all critical unit operations related to processing of both small molecules and biomolecules. The group is aiming for understanding the chemical and physical properties of the active pharmaceutical ingredients and excipients in relation to their processing behavior, and further, in relation to bioavailabity of the final dosage form. The research in group is focusing on facilitating the future implementation of Quality by Design (QbD) principles for drug development process.
Characteristic feature for our research is not only the world-leading quality, but also an attractive possibility for students to join one of our partner universities through our international network (PSSRC, Pharmaceutical Solid State Research Cluster). We have supervised students in several leading international academic units, as well as in several leading pharmaceutical companies.
For more information, see Pharmaceutical Solid State Research Cluster:
http://www.pssrc.org/

 
Selected examples of previous projects:
1. Investigation of rheological methods for  powder characterization (2011). Lundbeck
2. Investigation of peptide aggregation during freeze-drying (2011). Ferring
3. Increasing process understanding of inhalable formulations (2010). AstraZeneca, Lund
4. Insight into amorphous systems using multivariate approach (2010). University of Otago, New Zealand.
5. Effect of ions on viscosity and stability of highly concentrated liquid monoclonal antibody formulations- An evaluation of the Hofmeister effects (2010). Novo Nordisk A/S.
6. Protein adsorption to oil/water interfaces – influence of type and concentration of proteins and surfactants (2009). KU-FARMA

Examples of published work from previous M.Sc. projects (student name in boldface font):

JP Bøtker, P. Karmwar, C. Strachan, C. Cornett, F. Tian, Z. Zujovic, J. Rantanen, T. Rades, 2011. Assessment of crystalline disorder in cryo-milled samples of indomethacin using atomic pair-wise distribution functions. Int. J. Pharm. 417 112– 119
Y-Y Lee, J.X. Wu, M. Yang, P. Young, F. van den Berg, J. Rantanen, 2011. Particle size dependence of polymorphism in spray-dried mannitol. Eur. J. Pharm. Sci. 44 41-48.
S. Baldursdottir, F. Tian, B. Gallo Santacruz, A. Jørgensen, J. Rantanen, 2011. The influence of thermal history on the physical behavior of poly(ethylene glycol) (PEG). Pharm. Dev. Technol. (in press)
A. Baldinger, L. Clerdent, J. Rantanen, M. Yang and H. Grohganz, 2011. Quality by design approach in the optimization of the spray-drying process. Pharm. Dev. Technol. (in press)
 

 Forskningsgruppens hjemmeside:
Pharmaceutical Technology 

Specialevejledere
Alle vejledere sidder i bygning 13 - Nordblokken

Stefanía Baldursdottír
Adjunkt
E-mail: sba(at)farma.ku.dk
Telefon: 35 33 61 05
Rum: 716
Specialer:
F. eks. Formulering af makromolekylære lægemidler

Holger Grohganz
Adjunkt
E-mail: hgr(at)farma.ku.dk
Telefon: 35 33 64 73  
Rum: 714
Specialer:
F. eks. Processing af makromolekyler

Jørn Møller-Sonnergaard
Lektor
E-mail: jms(at)farma.ku.dk
Telefon: 35 33 62 71
Rum: 707
Specialer:
F.eks. Komprimering og komprimeringsegenskaber

Jukka Rantanen
Professor
E-mail: jtr(at)farma.ku.dk
Telefon: 35 33 65 85
Rum: 708
Specialer:
F.eks: Dry powder inhalation, DPI, at AstraZeneca, Lund

Mingshi Yang
Lektor
E-mail: my(at)farma.ku.dk
Telefon: 35 33 61 41
Rum 13 – 712

Kaisa Naelapää
Adjunkt
E-mail: kn(at)farma.ku.dk
Telefon: 35 33 61 55
Rum 13 – 710
Specialer: