Lars Olsen

2007 - : Associate professor, Faculty of Pharmaceutical Sciences, University of Copenhagen

2003-2007: Assistant professor, Danish University of Pharmaceutical Sciences (DFU) 

2003: Ph.D., the Royal Veterinary and Agricultural University (KVL), Denmark

2000: M.Sc.in physics and chemistry (Cand. Scient.), University of Copenhagen,  Denmark

Project leader on

• Cytochrome P450 Enzymes

Other interests

• Histone demethylase enzymes

• Ionotropic glutamate receptors

A complete list of publications 

Recent publications (2009-12)

2012

C. Krintel, K. Frydenvang, L. Olsen, M. T. Kristensen, O. de Barrios, P. Naur, P. Francotte, B. Pirotte, M. Gajhede, J. S. Kastrup
Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2
Biochemical Journal, 2012, 441, 173–178

J. Poehlsgaard, K. Harpsøe, F. S. Jørgensen, L. Olsen
A robust force field based method for calculating conformational energies of charged druglike molecule 
J. Chem. Inf. Model., 2012, 52, 409-419

P. Rydberg and L. Olsen
Ligand-Based Site of Metabolism Prediction for Cytochrome P450 2D6
ACS Med. Chem. Lett., 2012, 3, 69-73

P. Mikulskis, S. Genheden, P. Rydberg, L.  Sandberg, L. Olsen, U. Ryde
Binding affinities in the SAMPL3 trypsin and host-guest blind tests estimated with the MM/PBSA and LIE methods
J. Comp. Aided Mol. Design, 2012, DOI: 10.1007/s10822-011-9524-z

P. Rydberg, L. Olsen, U. Ryde
Quantum-mechanical studies of reactions performed by cytochrome P450 enzymes
Curr. Inorg. Chem., 2012, accepted for publication  

A. L. Nielsen, L. H. Kristensen, K. B. Stephansen, J. B. L. Kristensen, C. Helgstrand, M. Lees, P. Cloos, K. Helin,  M. Gajhede, L. Olsen
Identification of Catechols as Histone-Lysine Demethylase Inhibitors
FEBS Lett., 2012, accepted for publication

L. H. Kristensen, A. L. Nielsen, C. Helgstrand, M. Lees, P. Cloos, Paul, J.S. Kastrup, K. Helin, L. Olsen, M. Gajhede
Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridinedicarboxylic acid as an in vitro and in cell inhibitor.
FEBS J., 2012, accepted for publication

P. Rydberg, L. Olsen
Predicting drug metabolism by cytochrome P450 2C9 – comparison to the 2D6 and 3A4 isoforms
ChemMedChem, 2012, accepted for publication

J. Zaretzki, P. Rydberg, C. Bergeron, K. P. Bennett, L. Olsen, and C. M. Breneman
RS-Predictor models augmented with SMARTCyp reactivities:Robust metabolic regioselectivity predictions for nine CYP isozymes
J. Chem. Inf. Model., 2012, accepted for publication

2011

N. Kulahin, O. Kristensen, K. K. Rasmussen, L. Olsen, P. Rydberg, B. Vestergaard, J. S. Kastrup, V. Berezin, E. Bock, P. S. Walmod, and M. Gajhede
Structural Model and trans-Interaction of the Entire Ectodomain of the Olfactory Cell Adhesion Molecule
Structure 2011, 19, 203-211

J. B. L. Kristensen, A. L. Nielsen, L. Jorgensen, L. H. Kristensen, C. Helgstrand, L. Juknaite, J. L. Kristensen, J. S. Kastrup, R. P. Clausen, L. Olsen, M. Gajhede
Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases
FEBS Letters 2011, 585, 1951-1956.

B. Lohse, A. L. Nielsen, J. B. L. Kristensen, C. Helgstrand, P. A. C. Cloos, L. Olsen, M. Gajhede, R. P. Clausen, J. L. Kristensen
Targeting Histone Lysine Demethylases by Truncating the Histone 3 Tail to Obtain Selective Substrate-Based Inhibitors
Angew. Chem. Int. Ed., 2011, 39, 9100–9103 

P. Vasanthanathan, J. Lastdrager, C. Oostenbrink, J. N. M. Commandeur, N. P. E. Vermeulen, F. S. Jorgensen, L. Olsen
Identification of CYP1A2 ligands by structure-based and ligand-based virtual screening
MedChemComm 2011, 2, 853-859

P. Rydberg and L. Olsen
Do Two Different Reaction Mechanisms Contribute to the Hydroxylation of Primary Amines by Cytochromes P450
J. Chem. Theor. Comp., 2011, 7, 3399-3404

J. R. Kesting, L. Olsen, D. Staerk, M. V. Tejesvi, K. R. Kini, H. S. Prakash, J. W. Jaroszewski
Production of Unusual Dispiro Metabolites in Pestalotiopsis virgatula Endophyte Cultures: HPLC-SPE-NMR, Electronic Circular Dichroism, and Time-Dependent Density-Functional Computation Study
J. Nat. Prod., 2011, 74, 2206-2215 

2010

J. Andersen, L. Olsen, K.B. Hansen, O. Taboureau, F.S. Jørgensen, A.M. Jørgensen, B. Bang-Andersen, J. Egebjerg, K. Strømgaard, A.S. Kristensen
Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter 
J. Biol. Chem. 2010, 285, 2051-63.

A.L. Nielsen, F.S. Jørgensen, L. Olsen, S.F. Christensen, A.J. Benie,T. Bjørnholm, P.M. St. Hilaire
A Diversity Optimized Combinatorial Library for the Identification of Fc-Fragment Binding Ligands
Biopolymers, 2010, 94, 192-205

P. Rydberg, D. Gloriam, J. Zaretzki, C. Breneman, L. Olsen
SMARTCyp - a 2D method for Prediction of Cytochrome P450 Mediated Drug Metabolism
ACS Med. Chem. Lett., 2010, 1, 94-100.

D. H Omkvist, S. B Larsen; C. U. Nielsen, B. Steffansen; L. Olsen, F. S Jørgensen, B. Brodin
A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1)
AAPSJ, 2010, accepted for publication

P. Vasanthanathan, L. Olsen, F. S. Jorgensen,  N.P.E. Vermeulen, C. Oostenbrink
Computational Prediction of Binding Affinity for CYP1A2-Ligand Complexes Using Empirical Free Energy Calculations
DMD, 2010, 38, 1347-1354

The SMARTCyp cytochrome P450 metabolism prediction server
P. Rydberg, D. Gloriam, L. Olsen
Bioinformatics, 2010, 26, 2988-2989, 2010

2009

P. Vasanthanathan, O. Taboureau, C. Oostenbrink, N. P. E. Vermeulen, L. Olsen, F. S. Jørgensen
Classification of Cytochrome P450 1A2 Inhibitors and Non-Inhibitors by Machine Learning Techniques, Drug Metab. Disp., 2009, 37, 658-664

P. Vasanthanathan, J. Hritz, O. Taboureau, L. Olsen, F. S. Jørgensen, N. P. E. Vermeulen, C. Oostenbrink
Virtual Screening and Prediction of Site of Metabolism for Cytochrome P450 1A2 Ligands
J. Chem. Inf. Model, 2009, 49, 43-52.

J. Andersen, O. Taboureau, K.B. Hansen, L. Olsen, J. Egebjerg, K. Strømgaard, A. S. Kristensen
Location of the antidepressant binding site in the serotonin transporter: Importance of Ser438 in recognition of citalopram and tricyclic antidepressants
J. Biol. Chem., 2009, 284, 10276-10284.

S. B. Larsen, D. H. Omkvist, B. Brodin, C. U. Nielsen, B. Steffansen, L. Olsen, F. S. Jørgensen.
Discovery of Ligands for the Human Intestinal Di-/Tripeptide Transporter (hPEPT1) Using a QSAR-Assisted Virtual Screening Strategy.
ChemMedChem, 2009, 4, 1439-1445

P. Rydberg, L. Olsen.
The Accuracy of Geometries for Iron Porphyrin Complexes from Density Functional Theory.
J. Phys. Chem. A, 2009, 113, 11949-11953

P. Rydberg, P. Vasanthanathan, C.Oostenbrink, L.Olsen
Fast Prediction of Cytochrome P450 Mediated Drug Metabolism
ChemMedChem, 2009, 4, 2070-2079

A. Bach, C.N. Chi, G.F. Pang, L. Olsen, A.S. Kristensen, P. Jemth, K. Strømgaard
Design and synthesis of high potent and plasma-stable dimeric inhibitors of the PSD-95/NMDA receptor interaction.
Angew. Chem. Int. Ed., 2009, 48, 9685-9