Medicinal Chemistry (MedChem)
- Developing chemistry to understand biology
The overall focus of the medchem research group is the synthesis and development of new chemical probes that provide new information on biological systems.
Small molecules as well as modified peptides are designed and synthesized to study their interaction with different biological targets.
The research is multidisciplinary with focus on organic synthesis, molecular modeling, and structure-activity-relationship (SAR) investigations.
Most of the research projects address signaling systems in the brain. In these projects chemical probes are developed that can act in a selective manner on receptors and transporters in the central nervous system (CNS). Furthermore, research projects on epigenetic modulators with relation to both CNS and cancer diseases are ongoing.
The projects are conducted in collaboration with resarch groups in pharmacology, molecular and structural biology in order to investigate the effects of the compounds on the molecular, cellular and organism level.
Principal Investigators
The group is headed by the following Principal Investigators - click on the links below for an introduction them and some of their research projects.
People
Associate Professors
Rasmus P. Clausen
Bente Frølund (Group Coordinator)
Tommy N. Johansen
Jesper L. Kristensen
Brian Lohse
Ulf Madsen (Associate Dean)
Daniel Sejer Pedersen
Postdocs
Jan Bornholdt
Francois Crestey
Fredrik Diness
Matthias Herth
Charlotte G. Jørgensen
Stine B. Vogensen
PhD Students
Valdermar Andersen
Tinna Brøbech Bach
Anne Fuglsang Barslund
Magnus Bergner
Tue Heesgaard Jepsen
Henrik Johansson
Jacob Krall
Ulrike Leurs
Jette G. Petersen
Rune Risgaard
Niklas Sköld
Marie Thomsen
Mario de la Fuente Revenga (CSIC)
Master students
Morten Borch
Mads Lunde
Jesper Michelsen
Laura Osmani
Bjarke Sandersen
Maryam Sawa
Mona Kab Omir
Ida N. Petersen
Research assistant
Birgitte Nielsen
Technicians
Anette L. Eriksen
Ulla Geneser
Palle K. Sørensen
Professors
Mikael Begtrup (Emeritus)
Povl Krogsgaard-Larsen
Publications
The PI's in the MedChem Group has published more than 200 papers in international Journals over the last 10 years.
Please see the joint ResearcherID for the MedChemGroup here:
Funding
The following agencies are currently funding the activities in our laboratory:
The Lundbeck Foundation, The Danish Research Council, EU (Marie Curie Scholarship), Program of excellence - Epigenetics and Cancer, Danish Cancer Society,The Carlsberg Foundation and others.
