Mie Larsen
Videnskabelig assistent
E-mail: mla(at)farma.ku.dk
Telefon: 35 33 65 44
Rum : 13/419

In vitro characterisation of gaboxadol absorption
The proton-coupled amino acid transporter, PAT1, has been shown to be important for the absorption and thereby the delivery of some amino acid mimetic drugs. Recently the in vivo absorption of the GABA-analogue gaboxadol was shown to be dependent on PAT1 function. One essential step in the oral absorption of gaboxadol seems to be the translocation via PAT1 into the epithelial cells however; this needs to be characterized further. Moreover, the basolateral transport mechanism (transport from the epithelial cells to the blood) is still unknown. The aim of the project is therefore to characterise the apical and basolateral transport of gaboxadol in cell cultures. This project can be modified on the choice of substrate, the type of cell culture and the analytical method.
Vejleder: Mie Larsen
Max. antal studerende: 2