Monday, June 11th, 2007, Room J1, 3rd floor 

Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø

13:00 -

Molecular mechanisms of neuropathic pain
Professor Hiroshi Ueda from Nagasaki University

                    

 

 

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 Abstract

Neuropathic pain is different from nociceptive pain in terms of pain pathway from sensory neurons to spinal cord and brain. We have discovered that lysophosphatidic acid initiates the neuropathic pain through demyelination, which is supposed to cause allodynia due to cross-talk between noxious and innocuous sensory fibers.



Further reading:

LPA-mediated demyelination in ex vivo culture of dorsal root.
Neurochem Int. 2007 Jan;50(2):351-5. Epub 2006 Oct 23.


Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain.
Mol Pain. 2006 Aug 16;2:25.


Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling.
Nat Med. 2004 Jul;10(7):712-8. Epub 2004 Jun 13.

The symposium is organised on behalf of the Drug Research Academy, FARMA by Andreas Hald, Department of Pharmacology, The Faculty of Pharmaceutical Sciences, University of Copenhagen, e-mail ah(at)farma.ku.dk.

The participation is free of charge and is open for attendance by all interested parties. No registration is required.