The NPR group conducts research towards discovery of novel pharmacologically active compounds of natural origin.
The research combines rational selection of biodiversity resources, instrumental techniques of dereplication, pharmacological evaluation, and computer-based methods.
The studies provide a platform for exploration of structure-activity relationships using natural, semisynthetic, and synthetic compound libraries.
Key areas of interest are CNS-active and chemotherapeutic agents.
Leads of natural origin are optimized for selectivity and drugability. This comprises chemical modification of natural products by semi-synthesis as well as by total synthesis involving development of suitable parallel solid-phase methodologies.
Research projects are focused on biodiversity and evaluation of herbal remedies. Plants and other natural resources are rationally selected based on knowledge from traditional medicine or a predictive phylogenetic approach. Target species are screened for pharmacological activities. Promising extracts are subject to bioassay guided fractionation and structure elucidation of active compounds.
People
Professors
Søren B. Christensen
Dan Stærk
Associate professors
Henrik Franzyk
Paul Robert Hansen
Anna K. Jäger (Group leader)
Per Mølgaard (Emeritus)
Post docs
Nils T. Nyberg
PhD students
Jacob Clausen
Nhu Thi Quynh Doan
Rasmus Jahnsen
Christina Mernøe Jensen
Kenneth Johansen
Marianne Molander
Jens K. Munk
Eleonora Sandholdt Paulsen
Christina Schjøth-Eskesen
Jeppe Secher Schmidt
Gitte Bonke Seigan
Nicole Trier
Sileshi G. Wubshet
Ali Yilmaz
Technicians
Wan Adamsen
Sabaheta Babidic
Dorte Brix
Katrine Krydsfeldt
Huizen Liu
Birgitte Simonsen
Arife Önder
Teaching assistant
Jens Soelberg
