News

Kasper Pedersen successfully defended his master thesis on 27 Jan 2012. CONGRATULATIONS!

List of completed Ph.D., M.Sc. and B.Sc. projects

NeuroMet will be represented at the following meetings and courses in 2012:

10th International Conference on Brain Energy Metabolism, 17-20 April 2012, Monterey, CA, USA

Neuroscience 2012, the annual meeting of the Society of Neuroscience, 13-17 October 2012, New Orleans, LA, USA

12th Meeting of the European Calcium Society (ECS), 9-12 September 2012, Toulouse, France

Recent Publications

2012
Dam G., Keiding S., Munk O.L., Ott P., Vilstrup H., Bak L.K., Waagepetersen H.S., Schousboe A., Sørensen M. (2012) Hepatic encephalopathy is associated with decreased brain oxygen metabolism and blood flow, not increased ammonia uptake. Hepatology. In press

Skytt D.M., Klawonn A.M., Stridh M.H., Pajęcka K., Patrussa Y., Quintana-Cabrerab R., Bolaños J.P., Schousboe A., Waagepetersen H.S. (2012) SiRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate. Neurochem. Int. In Press

Leke R., de Oliveira D.L., Mussulinia B.H.M., M.S. Pereira, Kazlauckas V., Mazzinia G., Hartmann C.R., Silveira T.R., Simonsen M., Bak L.K., Waagepetersen H.S., Keiding S., Schousboe A., Portela L.V. (2012) Impairment of the organization of locomotor and exploratory behaviors in bile duct-ligated rats. PLoS ONE. In press

Bak L.K., Johansen M., Schousboe A., Waagepetersen H.S. (2012) Valine but not leucine or isoleucine supports neurotransmitter glutamate synthesis during synaptic activity in cultured cerebellar neurons. J. Neurosci. Res. In press

Kreft M., Bak L.K., Waagepetersen H.S., Schousboe A. (2012) Aspects of astrocyte energy metabolism, amino acid neurotransmitter homeostasis and metabolic compartmentation. ASN Neuro. In press

Bak L.K., Obel L.F., Walls A.B., Schousboe A., Faek S.A.A. , Jajo F.S., Waagepetersen H.S. (2012) Novel model of neuronal bioenergetics: Post-synaptic utilization of glucose but not lactate correlates positively with Ca²⁺ signaling in cultured mouse glutamatergic neurons. ASN Neuro. In press

Helms H.C., Madelung R., Waagepetersen H.S., Nielsen C.U., Brodin B. (2012) In Vitro Evidence for the Brain Glutamate Efflux Hypothesis: Brain Endothelial Cells Cocultured with Astrocytes Display a Polarized Brain-to-Blood Transport of Glutamate. GLIA. In Press

Obel L.F., Müller M.S., Walls A.B., Sickmann H.M., Bak L.K., Waagepetersen H.S., Schousboe A. (2012) Brain glycogen – new perspectives on its metabolic function and regulation at the subcellular level. Front. Neuroenergetics. In press

Sickmann H.M., Waagepetersen H.S., Schousboe A., Benie A.J., Bouman S.D. (2012) Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model. Neurochem. Int. 60(3):267-275. 

Obel L.F., Andersen K.M.H., Bak L.K., Schousboe A., Waagepetersen H.S. (2012) Effects of adrenergic agents on intracellular Ca²⁺ homeostasis and metabolism of glucose in astrocytes with an emphasis on pyruvate carboxylation, oxidative decarboxylation and recycling: Implications for glutamate neurotransmission and excitotoxicity. Neurotox Res. 21(4):405-417. 

Brekke E., Walls A.B., Nørfeldt L., Schousboe A., Waagepetersen H.S., Sonnewald U. (2012) Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation. Glia. 60(1):147-158.