NeuroMet
Neurometabolism Research Unit
The research in NeuroMet is focused on energy and amino acid metabolism in the mammalian brain. Primary mouse cell culture systems of neurons and astrocytes from cerebral cortex or cerebellum are extensively employed. In addition, acutely isolated cortical prisms, isolated mitochondria and cell lines are applied as model systems. An array of 3H, 15N and 13C isotopes is utilized in the mapping of metabolic pathways and their regulation. HPLC and mass spectrometry are key analytical tools combined with biochemical assays, protein biochemistry, molecular biology and fluorescence-based assays and imaging techniques.
News
Linea Obel successfully defended her PhD thesis on 12 Dec 2011. CONGRATULATIONS!
October 2011: Lasse K. Bak received a grant of 200,000 DKK from the Lundbeck Foundation!
October 2011: Margit Müller won an essay contest in Nature Chemistry! The essay appears in the December issue.
September 2011: Helle S. Waagepetersen received a grant of 2.6 million DKK from the Danish MRC!
NeuroMet will be represented at the following meetings and courses in 2012:
10th International Conference on Brain Energy Metabolism, 17-20 April 2012, Monterey, CA, USA
Recent Publications
2012
Sickmann H.M., Waagepetersen H.S., Schousboe A., Benie A.J., Bouman S.D. (2011) Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model. Neurochem. Int. in Press
Obel L.F., Andersen K.M.H., Bak L.K., Schousboe A., Waagepetersen H.S. (2011) Effects of adrenergic agents on intracellular Ca2+ homeostasis and metabolism of glucose in astrocytes with an emphasis on pyruvate carboxylation, oxidative decarboxylation and recycling: Implications for glutamate neurotransmission and excitotoxicity. Neurotox Res. In press
Brekke E., Walls A.B., Nørfeldt L., Schousboe A., Waagepetersen H.S., Sonnewald U. (2011) Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation. Glia. In press
Group members
Helle S. Waagepetersen, professor (Head of Unit), Ph.D.
Arne Schousboe, professor, D.Sc.
Lasse K. Bak, associate professor, Ph.D.
Karsten K. Madsen, post doc., Ph.D.
Malin Stridh, post doc., Ph.D.
Anne B. Walls, post doc., Ph.D.
Dorte Skytt, Ph.D. student, M.Sc.
Kamilla Pajecka, Ph.D. student, M.Sc.
Sherry Dadsetan, Ph.D. student, M.Sc.
Margit Müller, Ph.D. student, M.Sc.
Jakob Nissen, Ph.D. student, M.Sc.
Sofie Lange, M.Sc. (6 month internship)
Heidi Nielsen, laboratory technician
Louise Mørk, laboratory technician
Kasper Pedersen, master of science student, B.Sc.
Anne Hauge, master of science student, B.Sc.
Astrid Hestbæk, master of science student, B.Sc.
Rikke Søborg, master of science student, B.Sc.
Marie Simonsen, master of science student, B.Sc.
Katja Lassen, master of science student, B.Sc.
Camilla W. Nielsen, master of science student/lab assistent, B.Sc.
Peter Enevoldsen, master of science student, B.Sc.
Hanna Belcik, student lab assistant
