PET-ligands
- visualizing the 5HT-receptors in the CNS
Serotonin (5-HT) is an important neurotransmitter in the CNS where it modulates a plethora of diverse processes such as cognition, memory processing, mood, circadian behavior and appetite. Perturbations of this system have been linked to depression, obsessive compulsive disorder, schizophrenia, Alzheimer’s disease and migraine.
Positron emission tomography (PET) is a imaging technique which can be used to generate three-dimensional pictures of a given compounds distribution in the body. In affiliation with the research center CIMBI we are developing new selective PET ligangs for the serotonergic receptor system.
At Farma we are focussing on the devellopment of selective ligands for the respective targets - currently 5HT2A and 5HT7. We have identified a promising candidate for the 5-HT2A receptor which is currently avaiting human trials.
Key references
Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers. Ettrup, A.; Hansen, M.; Santini, M.A.; Paine, J.; Gillings, N. Palner, M.; Lehel, S.; Herth, M.M.; Madsen, J.; Kristensen, J.; Begtrup, M.; Knudsen, G.M. Eur. J. Nucl. Med. Mol. Imaging, 2011, 38, 681. PDF
People
Ida N. Petersen
Valdemar Andersen
Matthias Herth
Jesper L. Kristensen
Specialeprojekt
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