DRA Minisymposium: Peripheral Effects of Opioids
Monday, February 28th, 2005 in the Benzon Auditorium
The Danish University of Pharmaceutical Sciences Universitetsparken 2, 2100 Copenhagen O
Background
In treating pain with opioids, it is always possible to achieve total pain relief, however not always without the patient suffering from unacceptable side-effects. Thus pain treatment with opioids will often be a balance between sufficient analgesia and occurrence of side-effects. A balance, which could only be determined by the individual patient.
It was not until the early 1970'ies that the mechanisms of which opiods exerts their analgesic action as well as their side-effects by interaction with receptors were elucidated, and until recently these receptors were believed to be present only in the CNS at spinal and supraspinal level. However, during the past 10-15 years it has become evident that at least during pathological conditions (i.e. inflammation) opioid receptors are present also in the peripheral nerve system. Thus the interaction of opioids with peripheral opioid receptors probably contributes to the clinical effects of opioids.
Program
| 14:00-14:10 | Introduction |
| 14:10-14:45 | Opioid peptide production in immune cells Melanie Busch, Klinik für Anaesthesiologie und operative Intensivmedizin Charité - Universitätsmedizin Berlin Campus Benjamin Franklin |
| 14:45-15:20 | Anti-inflammatory effects of opioids Michael Schäfer, Klinik für Anaesthesiologie und operative Intensivmedizin Charité - Universitätsmedizin Berlin Campus Benjamin Franklin |
| 15:20-15:50 | Coffee Break |
| 15:50-16:25 | Pro- versus analgesic actions of immune cells Heike Rittner, Klinik für Anaesthesiologie und operative Intensivmedizin Charité - Universitätsmedizin Berlin Campus Benjamin Franklin |
| 16:25-17:00 | Immunosuppression by opioids - clinical evidence Christoph Stein, Klinik für Anaesthesiologie und operative Intensivmedizin Charité - Universitätsmedizin Berlin Campus Benjamin Franklin |
| 17:00-17:30 | Discussion and Conclusion Flemming Bach, Department of Neurology, Århus University Hospital |
The symposium is open for all interested. No registration required.
Joint meeting between DRA and Dansk Videnscenter for Opioider (Danish Opioid Science Centre). Organized by Associate Professor Lona Christrup and associate Professor Erik Wind Hansen, The Danish University of Pharmaceutical Sciences and Chief consultant, MD Niels-Henrik Jensen, The Multidisciplinary Pain Centre, Herlev University Hospital.
