DRA Lecture: Potent and Selective Non-Peptide Human Somatostatin Receptor Subtype-2 (hsst2) Agonists
<typohead type="4" align="left">Thursday, October 28th, 2004 at 15:15 in the Benzon Auditorium</typohead>
The Danish University of Pharmaceutical Sciences Universitetsparken 2, 2100 Copenhagen O
Alexander Pasternak, PhD
Merck Research Laboratories
Rahway, USA
Abstract
"Through a multidisciplinary effort involving molecular modeling, combinatorial and medicinal chemistry, and biology, a series of highly potent and selective nonpeptide somatostatin subtype 2 receptor (sst2) agonists were discovered. These compounds are efficacious in dogs, rats and mice in lowering growth hormone, glucagon, and glucose levels after IV and subcutaneous administration. The poor oral bioavailability characteristics of this class was overcome by a synergistic series of modifications. The resulting next generation compounds were potent and selective sst2 agonists, now having good oral bioavailability and oral efficacy."<?/x-tad-smaller><?/color><?/fontfamily>
The lecture is organised by: Prof. Mikael Begtrup (the Danish University of Pharmaceutical Sciences) and is open for attendance by all interested parties.
