Publications 2012
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Bach A, Clausen BH, Møller M, Vestergaard B, Chi CN, Round A, Sørensen PL, Nissen KB, Kastrup JS, Gajhede M, Jemth P, Kristensen AS, Lundström P, Lambertsen KL, Strømgaard K. A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. Proc Natl Acad Sci U S A (PNAS). 2012, 109(9):3317-3322.
Christensen SB, Bygbjerg IC. Drugs for the neglected disease malaria based on natural products. I: Tringali C, Ed. Bioactive compounds from natural sources: natural products as lead compounds in drug discovery. 2nd ed. Boca Raton: CRC Press. Taylor & Francis Group. 2012, p. 525-550.
Crestey F, Hooyberghs G, Kristensen JL. Concise synthesis of new bridged-nicotine analogues. Tetrahedron. 2012, 68(5):1417-1421.
Haq SR, Chi CN, Bach A, Dogan J, Engström Å, Hultqvist G, Karlsson OA, Lundström P, Montemiglio LC, Strømgaard K, Gianni S, Jemth P. Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains. J Am Chem Soc. 2012, 134(1):599-605.
Holler JG, Søndergaard K, Slotved H, Gúzman A, Mølgaard P. Evaluation of the antibacterial activity of Chilean plants traditionally used for wound healing therapy against multidrug-resistant Staphylococcus aureus. Planta Med. 2012, 78(2):200-205.
Kaae BH, Harpsøe K, Kvist T, Mathiesen JM, Mølck C, Gloriam DE, Jimenez HN, Uberti MA, Nielsen SM, Nielsen B, Bräuner-Osborne H, Sauerberg P, Clausen RP, Madsen U. Structure-activity relationships for negative allosteric mGluR5 modulators. ChemMedChem. 2012, 7(3):440-451.
Krintel C, Frydenvang K, Olsen L, Kristensen MT, de Barrios O, Naur P, Francotte P, Pirotte B, Gajhede M, Kastrup JS. Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. Biochem J. 2012, 441(1):173-178.
Molander M, Christensen SB, Jäger AK, Olsen CE, Rønsted NAH. 6-O-Methylkrigeine, a new Amaryllidaceae alkaloid from Nerine huttoniae Schönland. Nat Prod Res. 2012, 26(1):56-60.
Nilsson J, Nielsen EØ, Liljefors T, Nielsen MPC, Sterner O. 3-Alkyl- and 3-amido-isothiazoloquinolin-4-ones as ligands for the benzodiazepine site of GABAA receptors. Bioorg Chem. 2012, 40:125-130.
Pan Y, Gerasimov MR, Kvist T, Wellendorph P, Madsen KK, Pera E, Lee H, Schousboe A, Chebib M, Bräuner-Osborne H, Craft CM, Brodie JD, Schiffer WK, Dewey SL, Miller SR, Silverman RB. (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction. J Med Chem. 2012, 55(1):357-366.
Poehlsgaard J, Harpsøe K, Jørgensen FS, Olsen L. A robust force field based method for calculating conformational energies of charged drug-like molecules. J Chem Inf Model. 2012, 52(2):409-419.
Rohde LAH, Ahring PK, Jensen ML, Nielsen EØ, Peters D, Helgstrand C, Krintel C, Harpsøe K, Gajhede M, Kastrup JS, Balle T. Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine α4β2 receptors: Unique role of halogen bonding revealed. J Biol Chem. 2012, 287(6):4248-4259.
Rydberg P, Olsen L. Ligand-based site of metabolism prediction for cytochrome P450 2D6. ACS Med Chem Lett. 2012, 3(1):69-73.
Thomsen ARB, Hvidtfeldt M, Bräuner-Osborne H. Biased agonism of the calcium-sensing receptor. Cell Calcium. 2012, 51(2):107-116.
Tosco P, Balle T. A 3D-QSAR-driven approach to binding mode and affinity prediction. J Chem Inf Model. 2012, 52(2):302-307.
