Rational Oral Drug Delivery

The Aims of the groups’ research:
The conventional immediate release tablet or capsule has had its time of glory. Drugs in development today crave sophisticated oral drug delivery systems for protection, solubilisation or delivery to specific sites in the gastro-intestinal (GI) tract. The absorption of orally administered drugs, is profoundly affected by the physiology of the upper GI tract. We strive to understand the mechanisms involved, avoid the pitfalls and exploit the opportunities to achieve better or at least more predictable bioavailability. In order to achieve better absorption, reduced incidence or severity of side effects and to improve compliance and convenience, novel drug delivery systems are needed. Our particular interest lies with the oral route because of its acceptance by the patients.
We develop biopharmaceutical tools that enable a rational development of oral drug delivery systems. We develop in vitro methods simulating the dissolution, solubilization, digestion and absorption processes in the GI tract. Our projects span from solubility and dissolution in simulated GI fluids; digestion of lipid based delivery systems, transport studies in Caco-2 cells and intestinal tissue, to development of novel delivery systems and test in animal model. We use Design-of-Experiment software for development of delivery systems and Simulation software to establish in vivo - in vitro correlations/relations (IVIVC/R) – based on our experimental work.
We explore “less conventional” dosage forms such as chewing gums, nano-emulsions and puddings as vectors. We try to understand what makes a dosage form more attractive/acceptable, also for “special” populations such as children, youngsters and the elderly and to use the knowledge obtaining in designing better dosage forms.

Forskningsgruppens hjemmeside

Rational Oral Drug Delivery

Specialevejledere
Alle vejledere sidder i bygning 13 - Nordblokken

Anette Müllertz
Lektor
E-mail: amu(at)farma.ku.dk
Telefon: 35 33 64 40
Rum: 321
Oral biotilgængelighed, tungt opløselige lægemiddelstoffer, udvikling af selv-emulgerende nano-emulsioner ved hjælp af in vitro lipolyse, solubiliseringsmekanismer, biorelevante medier, lipid-baserede formuleringer.
Specialer

• In vitro og in vivo undersøgelser af vehikler
• Oral absorption – effekt af faste, føde eller fordøjelse
• Intestinal lymfatisk transport af tungtopløselige lægemiddelstoffer
• Forbedring af biotilgængelighed af svært vandopløselige lægemidler med brug af mikroemulsioner

Jette Jacobsen 
Lektor
E-mail: jeja(at)farma.ku.dk
Telefon: 35 33 62 99
Rum: 305a
Oral biotilgængelighed, tungt opløselige lægemiddelstoffer, intestinal (lymfatisk) absorption, bukkal absorption, in vitro modeller (cellekultur, Ussing kammer) for permeabilitet og toxicitet af lægemiddelstoffer/hjælpestoffer/formuleringer, biorelevante medier, medicinsk tyggegummi.
Specialer 

• In vitro og in vivo undersøgelser af vehikler
• Oral absorption – effekt af faste, føde eller fordøjelse
• Intestinal lymfatisk transport af tungtopløselige lægemiddelstoffer
• Kontrolleret frigivelse af aktiv stoffer og smag (aroma, sødestoffer) fra komprimat tyggegummi

Huiling Mu
Lektor
E-mail: hum(at)farma.ku.dk
Telefon: 35 33 61 87
Rum 13/317
Oral biotilgængelighed, tungt opløselige lægemiddelstoffer, udvikling af selv-emulgerende nano-emulsioner ved hjælp af in vitro lipolyse, solubiliseringsmekanismer, biorelevante medier, lipid-baserede formuleringer
Specialer

Daniel Bar-Shalom
Lektor
Telefon: 35 33 63 51
Rum 13 - 305a
Oralt Kontrollered Agfit af Lægemiddelstoffer (Controlled Release (CR) Drug Delivery, ). Erosions baserede  CR, CR for børn. Oralrt administration til de ældre. Automatiseret Magistrel fremstilling af orale præparater.
Specialer

Pernille Barbre Pedersen
Phd studerende
E-mail: pbb(at)farma.ku.dk
Telefon: 35 33 61 25
Rum: 13/318
Specialer

Ping Li
Phd studerende
E-mail: pl(at)farma.ku.dk
Rum 13 - 334
Specialer

Latest master thesis:
Forbedret bukkal retention af et vandopløseligt lægemiddelstof ved brug af bioadhæsive formuleringer. Frederiksen S. August 2010.

Development of a gastric step for the dynamic in vitro lipolysis model. Linda Grøn Jensen. September 2010.

Characterisation of human mechanically acid stimulated saliva and assessment of its role in an ex vivo model simulating the retention of spray dried bio-adhesive chitosan particles for the oral cavity. Katrine Dragsbæk Madsen. May 2011

Forbedret oromucosal retention og adhæsion af et vandopløseligt lægemiddelstof indkapslet I alginate – indflydelse af krydsbinding med calcium og sammensætning af alginate. Morten Bendix Jensen. August 2011

Buccal absorption of metoprolol – in vivo studies of pH dependency of gels and bioadhesive tablets administered in minipigs and rats. Mads Lindgreen Jesperen og Morten Baltzer Andersen. September 2011

Design of experiments and optimization of self-emulsifying drug delivery systems, Azeddine Chtatou, December 2010
In vitro and in vivo studies of a non-invasive model for bile-depletion in rats. Janne Zander Hesselkilde. August 2011 (Udført på Lundbeck)

Micellær solubilisering af insulin og insulin komplekser med henblik på at øge den oral absorption. Abderrahman Bojazar & Waseem Rashed. August 2011. (Udført på Novo Nordisk)