Today more than 40% of the new drug substances possess a very low solubility in water. Many of these compounds are considered "Class 2 substances", meaning that they have a high permeability, but that their low solubility is the limiting factor for the absorption in the body. Consequently, it is important to investigate the factors which determine the solubility in the intestine and to develop formulations which can increase it.

The aim of the GISOL-group is to develop in vitro methods which simulate the environment in the intestinal tract. The correlation between the in vitro and the in vivo conditions is investigated by means of clinical or animal studies. Both in vitro and in vivo studies are primarily carried out with our lipid-based formulations, for instance micro-emulsions, self-emulsifying systems or dry emulsions.