Retrovirus assembly

HIV project: We have earlier have indicated that the sequence PLASL binds to the HIV preprotein Gag. This sequence is also a part of of the HIV protein p6. P6 has importance for the infectious pathway, especially controlling budding by controlling membrane traffic. Secondly p6 binds to the HIV protein Vpr, which controls the entry. Many other cellular proteins have shown to interfere with p6. We have set out to find the sequences of other proteins which binding to p6 using phage display. In another project, the assembly of murine retrovirus proteins in cells before budding is investigated.