Advanced Pharmacognosy (- afholdes ikke)
Fagkode / Course code:
Eksamenskode / Exam code:
Gyldig fra / Valid from: August 2012
MSc in Pharmaceutical Sciences - elective, MSc in Medicinal Chemistry - elective, Cand.Scient.Pharm. - elective, Cand.Pharm. - elective
Open for Danish and international guest students with a background in pharmacy or relevant life or health sciences.
Placering / Time Schedule:
Block 1, Timetable group C
Timetal / Contact hours:
- Seminars: 32 hours
- Laboratory exercises: 40 hours
- Excursion: 8 hours
Undervisningsmateriale / Course materials:
Selected scientific articles and practical laboratory manual prepared by subject teachers are available on the course home page.
Prøveform / Examination type:
Laboratory practice, approved reports, poster and oral presentations are required before students can take the examination. The examination consists of a literature project and multiple choice tests (weight 1:1)
Prøvebedømmelse / Examination assessment:
7-point grading scale
Prøvebedømmere / Examiners:
Course Teacher(s) without external examiner
Tilladte hjælpemidler / Permitted aids:
Sprog / Language:
Kursuskapacitet / Capacity:
Formål / ObjectiveThe course aims to give students insight into the advantage of using ethnopharmacology and chemotaxonomy as a background for screening plants for potential drugs. Students will have the opportunity for a high level study of a biological topic in depth, where different elements will be combined in an interdisciplinary course with secondary plant metabolites as the common denominator. The course provides practical knowledge of phytochemical methods and some of the bioassays used to test traditional medicine for pharmacological activity.
Forudsætninger / PrerequisitesStudents should have a basic knowledge of pharmacognosy and natural products chemistry. Students are expected to know their way around a chemistry laboratory.
Målbeskrivelse / Course outcomeAt the end of the course, students should have:
- Have acquired knowledge about secondary metabolites in the plant kingdom and an understanding of their distribution, possible function in the plant, and pharmacological effects.
- Have acquired understanding of ethnopharmacological issues and working methods in order to evaluate the quality of ethnopharmacological studies and be able to plan and conduct their own.
- Be able to carry out in vitro screening of plant extracts.
Indhold / ContentThe teaching combines a theoretical and a practical segment.
The theoretical segment deals with the occurrence and function of secondary metabolites in plants. Examples of the role of secondary metabolites in nature will be presented, and their role as moderators in plant-animal/ plant-plant and plant-pathogen interactions will be reviewed. Examples will be discussed where there has been co-evolution between plants and animals that have common biochemical denominators. Scientific articles will be used to illustrate the objectives and methods of ethnopharmacology: to develop and improve the substances used in traditional medicine, and to find new potential drug substances for use in modern medicine. The development of traditional medicine should include an evaluation of efficacy and safety, as well as the establishment of formulation methods for standardised preparations. Students will both study examples of new drugs found by ethnopharmacological research and examples of traditional medicines whose pharmacological effect was verified through clinical testing. The theoretical segment of the course will include a literature project to train students in critical interpretation of published literature.
The practical part of the course will include studying various extraction and separation methods for secondary metabolites as well as in vitro assays for bioactivity.
Beståkrav / Pass criteriaCourse assessment is in three parts: a pass-fail assessment of the laboratory course, a partial grade based on the literature project and a partial grade for the multiple-choice tests. Both partial grades are based on the 12-point scale. The final grade for the course will be calculated as the average of the two partial grades in accordance with the following rules:
Guidelines for improving partial grades:
- The literature assignment and multiple-choice tests must each be assessed at minimum 02.
- The grade average is rounded to the closest grade. If the exam average is between two grades, it will be rounded up.
- A partial grade is valid for up to five years, after which the entire course must be repeated.
- The Department of Medicinal Chemistry is responsible for storing all partial grades for five years.
Karakterbeskrivelse / Description of gradesGrading scale for the literature assignment:
12 - Excellent performance
7 - Good performance
- In the report the examinee has demonstrated having made an exhaustive literature search and having selected the most important references for the article chosen.
- In the report the examinee has demonstrated a convincing ability to reference a scientific article, extract the most important topics for his or her own understanding and for communicating significant information.
- The examinee has demonstrated convincing use of specialized terminology and of the standards for written presentation.
- The report reads well as a whole.
02 - Acceptable performance
- In the report the examinee has demonstrated having made a comprehensive literature search and having selected important references for the article chosen.
- In the report the examinee has demonstrated the ability to reference a scientific article, to extract important topics for his or her own understanding and for communicating significant information.
- The examinee has demonstrated familiarity with specialized terminology and with the standards of written presentation.
- The report reads well as a whole.
Grading scale for the multiple-choice tests:
On On the basis of the student’s performance on the multiple-choice tests, an overall assessment (in %) will be made of the student’s:
- In the report the examinee has demonstrated having made an acceptable literature search and having selected some important references for the article chosen.
- The examinee has demonstrated the ability to understand and reproduce relevant parts of the selected literature
- The examinee has demonstrated knowledge of specialized terminology and of the standards for written presentation.
For each multiple-choice question the correct answer equals 1 point, a wrong answer equals –1 point, and no answer equals 0 points. Correct answers to all the multiple-choice questions are set at 100%. The pass requirement is 50% of the maximum number of points possible in the multiple-choice tests.
- Knowledge of the distribution of secondary metabolites in the plant kingdom, their function in the plant and their relationship to pharmacological effect
- Knowledge of ethnopharmacological questions and working methods
- Knowledge of the isolation of secondary metabolites from biological material
- Knowledge of bioassays
- Understanding of central representation forms in the field.
Preparation for laboratoy exercises|10
Independent studies incl. literature project and assessment|116
Total no. of hours|206
Kursusansvarlig / Course directorAnna K. Jäger
, Department of Drug Design and Pharmacology