Structure and Dynamics of the Human beta 2 Adrenoceptor
Wednesday, August 15th, 2007, Benzon Auditorium
Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø
Program
10:00 - 11:00
Structure and Dynamics of the Human beta 2 Adrenoceptor
Guest lecturer, Brian Kobilka, MD
Professor of Medicine and Molecular and Cellular Physiology
Stanford University
Beckman Center
Stanford, USA
The lecture will be opened by Peter Høngaard Andersen, cand.scient, dr.med. Vice President, Head of Research, H. Lundbeck A/S
Abstract
G protein coupled receptors (GPCRs) are remarkably versatile signaling molecules. The beta 2 adrenoceptor (beta2AR) is a prototypical Family A GPCR that mediates physiologic responses to adrenaline and noradrenaline. The function of the beta2AR can be modulated by the spectrum of synthetic ligands including full agonists (maximal activation), partial agonists (submaximal activation), neutral antagonists (no biological effect), and inverse agonists (inhibit basal activity). The beta2AR and many other GPCRs exist as dimers or oligomers in the plasma membrane, yet the functional role for dimers is not fully understood. We have used biochemical and biophysical approaches to map ligand-induced conformational changes in the beta2AR, and to characterize the structure and function of beta2AR dimers. I will discuss these studies as well as our recent progress towards obtaining a high-resolution structure of the human beta2AR by X-ray crystallography.
The symposium is organised on behalf of the Drug Research Academy, FARMA by Peter Høngaard Andersen, Vice President, Head of Research, H. Lundbeck A/S, e-mail phqa(at)lundbeck.com
The participation is free of charge and is open for attendance by all interested parties. No registration is required.
