Anne B. Walls, post doc., Ph.D.
Dept. of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen
2 Universitetsparken
2100 Copenhagen, Denmark
Phone +45 35336363
Fax +45 35336021
E-mail: abw(at)farma.ku.dk
Research and teaching
Research Section: Molecular and Cellular Pharmacology
Research Unit: Neurometabolism
Primary research interests:
- Importance of glycogen for neurotransmission and brain function
- Importance of the two isoforms of GAD, GAD65 and GAD67, for synthesis of GABA
A description of the applied methodology may be found on the Research Unit web page.
Teaching:
B-26 Organ-related Pharmacology
Pharmacology: From Physiology to Therapy
Short CV
Education
September 2010: Doctor Philos (ph.d), Norwegian University of Sciece and Technology (NTNU), Trondheim
February 2006: M.Sc. in pharmacy, Danish University of Pharmaceutical Sciences
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Employment
June 2005-December 2005: Scholar stipend, Dept. of Pharmacology and Pharmacotherapy, Danish University of Pharmaceutical Sciences financed by the Danish Medical Research Counsil.
February 2006-December 2006: Research assistant, Dept. of Pharmacology and Pharmacotherapy, Danish University of Pharmaceutical Sciences
March 2006-May 2006: Collaboration with Glycom with funding of salary
June 2006 2006: Collaboration with Martin Lauritzen, The Panum Institute, University of Copenhagen, with funding of salary
November 2006-December 2006 Collaboration with Ursula Sonnewald, Norwegian University of Science and Technology, with funding of salary
January 2007-September 2010: Enrolled as Dr. Philos student at the Norwegian University of Science and Technology, Trondheim, Norway. Supervisors: Ursula Sonnewald, Arne Schousboe and Helle S. Waagepetersen
January 2007-December 2010: Research assistant, Dept. of Pharmacology and Pharmacotherapy, FARMA, University of Copenhagen
January 2011-December 2013: Post doc., Dept. of Pharmacology and Pharmacotherapy, FARMA, University of Copenhagen financed by the Danish Medical Research Counsil.
Other relevant activities
October 2006: Period of study, Dept. of Neurological Surgery, University of Rochester Medical Center, Rochester, NY, USA. Supervisor: Professor Maiken Nedergaard
List of Publications
Original papers
Brekke E., Walls A. B., Nørfeldt L., Schousboe A., Waagepetersen H. S., Sonnewald U. (2012) Direct measurement of backflux between oxaloacetate and fumarate following Pyruvate carboxylation. GLIA Jan;60(1):147-58.
Walls A. B., Nilsen L. H., Eyjolfsson E. M., Vestergaard H. T., Hansn S. L., Schousboe A., Sonnewald U., Waagepetersen H. S. (2010) GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity. Journal of Neurochemistry Dec;115(6):1398-408.
Walls A. B., Eyjolfsson E. M., Smeland O. B., Nilsen L. H., Schousboe I., Schousboe A., Sonnewald U., Waagepetersen H. S. (2010) Knockout of GAD65 has major impact on synaptic GABA derived from astrocytic glutamine. Journal of Cerebral Blood Flow and Metabolism. In press.
Bak L. K., Walls A. B., Schousboe A., Ring A., Sonnewald A., Waagepetersen H. S. (2009) Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels. Journal of Neurochemistry 109 (suppl. 1): 87-93.
Sickmann H. M., Walls A. B., Bouman S. D., Schousboe A., Waagepetersen H. S. (2009) Functional significance of brain glycogen in sustaining glutamatergic transmission. Journal of Neurochemistry 109(suppl. 1): 80-86.
Walls A. B., Heimbürger C. M., Bouman S. D., Schousboe A., Waagepetersen H. S. (2009) Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents. Neuroscience 158(1): 284-292.
Walls A.B., Sickmann H. M., Brown A. M., Bouman S. D., Ransom B., Schousboe A., Waagepetersen H. S. (2008) Characterization of 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) as an inhibitor of brain glycogen shunt activity. Journal of Neurochemistry 105(4): 1462-70.
Caesar K., Hashemi P., Douhou A., Bonvento G., Boutelle M. G., Walls A. B., Lauritzen M. (2008) Glutamate receptor dependent increments in lactate, glucose and oxygen metabolism in rat cerebellum. The Journal of Physiology 586(5): 1337-49.
Review papers
Schousboe A., Sickmann H. M., Walls A. B., Bak L. K., Waagepetersen H. S. (2010) Functional importance of the astrocytic glycogen shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient. Neurotox Res. 2010 Jul;18(1):94-9.
